前列地尔联合丹参注射液治疗高脂血症性急性胰腺炎的疗效观察  

Effect of alprostadil combined with Salvia miltiorrhiza in treatment of hyperlipidemic acute pancreatitis

作　　者：俞晶[1] 郑彦丰[1] 林霓[1] 吴瑞暖 刘朝晖[1] 陈素钻[1] 郭光华[1] 

机构地区：[1]汕头大学医学院第一附属医院消化内科,广东省汕头515041

出　　处：《中国基层医药》2015年第23期3570-3572,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨前列地尔联合丹参注射液治疗高脂血症性急性胰腺炎的效果。方法将高脂血症性急性胰腺炎患者根据随机数字表法分为对照组和治疗组，每组32例，对照组予常规治疗加前列地尔10μg静脉注射，治疗组在对照组基础上予丹参注射液20 mL 静脉输液，比较两组腹痛缓解时间、APACHE-Ⅱ和CRP 水平变化以及预后、住院时间和费用。结果治疗组患者接受治疗后，治疗组腹痛缓解时间（5．31±1.09）d，APACHE-Ⅱ评分（2．34±1．18）分，C 反应蛋白水平（48．41±22．64）mg／L 均优于对照组（8．16±1.39）d，（4.47±1．68）分和（65．34±18．02）mg／L，差异均有统计学意义（t ＝9．08、0．14、5．84、－0．49、3．31，均P ＜0.05）；治疗期间，两组病死率差异无统计学意义（P ＞0．05），但对照组手术率31．25％（10／32）高于治疗组6.25％（2／10），治疗组住院总时间（14．50±1．55）d 及总费用（4．97±1．00）万元均低于对照组的（16．78±1．83）d 和（5．72±1．71）万元，经比较差异均有统计学意义（χ2＝6．65、t ＝1．00、t ＝5．39，均 P ＜0．05）。结论前列地尔联合丹参注射液治疗高脂血症性急性胰腺炎效果好，能缩短患者病程，减少住院时间和费用，提高治愈率。Objective To investigate the effect of alprostadil combined with Salvia miltiorrhiza in treatment of hyperlipidemic acute pancreatitis.Methods Patients with high cholesterol of hyperlipidemic acute pancreatitis were randomly divided into control group and treatment group,32 cases in each group.The control group were treated with conventional therapy combined with alprostadil 10μg intravenous injection,the treatment group was given Salvia miltiorrhiza injection 20mL vein infusion on the basis of the control group.The abdominal pain relief time,APACHE -II,C reactive protein levels,prognosis,hospitalization time and cost were compared between the two groups.Results The abdominal pain relief time,APACHE -II score,C reactive protein level in the treatment group were （5.31 ± 1.09）d,（2.34 ±1.18）,（48.41 ±22.64）mg/L,which were better than those in the control group （8.16 ±1.39）d, （4,47 ±1.68）and （65.34 ±18.02）mg/L,the differences were statistically significant （t =9.08,0.14,5.84,-0.49,3.31,all P〈0.05）.There was no difference in mortality between the two groups （P〉0.05）.The operation rate of control group was 31.25% （10 /32）,which was significantly higher than that of the treatment group [6.25%（2 /10）],the total hospitalization time,total cost of the treatment group were （14.50 ±1.55 ）d and （4.97 ± 1.00）ten thousand yuan,which were significantly lower than those of the control group （16.78 ±1.83）d and （5.72 ± 1.71）ten thousand yuan,the differences were statistically significant （χ2 =6.65,t =1.00,t =5.39,all P〈0.05）. Conclusion Alprostadil combined with Salvia miltiorrhiza injection in the treatment of hyperlipidemia hyperlipidemia acute pancreatitis is safe,has good treatment effect,and can shorten the course of disease,reduce patients＆#39;hospitaliza-tion time and cost,and effectively improve the cure rate.

关 键 词：胰腺炎 高脂血症 前列地尔 丹参 

分 类 号：R576[医药卫生—消化系统]