原发性胆汁反流性胃炎患者血清胃泌素与血浆胃动素水平的临床观察  

Clinical observation of serum gastrin and the plasma motilin levels in 80 patients with primary bile reflux gastritis

作　　者：李立胜[1] 

机构地区：[1]镇江市第四人民医院消化科,江苏省镇江212001

出　　处：《中国基层医药》2015年第23期3591-3593,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察原发性胆汁反流性胃炎患者血清胃泌素与血浆胃动素的变化。方法选择原发性胆汁反流性胃炎患者80例，观察其血浆胃动素（MTL）与血清胃泌素（GAS）含量，并与同期体检的80例健康人血浆胃动素（MTL）与血清胃泌素（GAS）水平进行对比分析。结果研究组血浆 MTL 含量为（282．37±31.56）pg／mL，明显低于对照组（t ＝－21．352，P ＜0．01）；研究组血清 GAS 含量为（91．28±27．71）pg／mL，明显高于对照组（t ＝－28．388，P ＜0．01）。结论与健康人比较，原发性胆汁反流性胃炎患者胃动素分泌存在不足的现象，而其胃泌素则分泌过量，这有可能是此病的一个发病因素。Objective To observe the changes of serum gastrin （GAS）and plasma motilin （MTL）in patients with primary bile reflux gastritis.Methods 80 patients with primary bile reflux gastritis were selected.The serum GAS and plasma level of MTL were observed,and the results were compared with 80 healthy people.Results The content of MTL in plasma of the study group （282.37 ±31.56）pg/mL was significantly lower than that in the control group （t =-21.352,P〈0.01）.The level of serum GAS （91.28±27.71）pg/mL was significantly higher than the control group （t =-28.388,P〈0.01）.Conclusion Compared with the healthy people,secretion of MTL in patients with primary bile reflux gastritis has insufficient phenomenon,and has the excessive secretion of GAS in the body,this may be a factor in the pathogenesis of the disease.

关 键 词：胃炎 胆汁返流 胃泌素 胃动素 

分 类 号：R573.3[医药卫生—消化系统]