脂肪肝患者血清生化指标及其相关性分析  

Analysis of serum biochemical parameters and their correlations in fatty liver patients

作　　者：张秀芝 刘晓丽[2] 李宁宁 亢春彦 陈洁 张进忠 

机构地区：[1]河南医学高等专科学校,河南郑州451191 [2]河南省人民医院,河南郑州450003

出　　处：《中国卫生检验杂志》2015年第23期4066-4067,4070,共3页Chinese Journal of Health Laboratory Technology

基　　金：河南省科技攻关计划项目(142102310441)

摘　　要：目的探讨脂肪肝患者肝功能和血脂等血清生化指标的改变并对其相关性进行分析。方法收集来自河南省人民医院体检中心61名脂肪肝患者的体检资料,并与122名健康体检者的资料进行比较。结果脂肪肝患者组血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)、碱性磷酸酶(ALP)和γ-谷氨酰转移酶(γ-GGT)明显高于正常对照组,差异有统计学意义(P<0.05);血脂指标中,脂肪肝患者总甘油三酯(TG)明显高于对照组,高密度脂蛋白(HDL)明显低于对照组(P<0.05)。脂肪肝患者组血清AST与ALT之间、TBIL与DBIL之间分别呈明显正相关(P<0.05);HDL与ALT、AST、DBIL、ALP、γ-GGT之间分别呈明显负相关(P<0.05);TG与其他各指标之间未见明显的相关性(P>0.05)。结论高水平TG和低水平HDL是脂肪肝发生过程中相对独立的危险因素;脂肪肝患者虽然大多组无自觉症状,但其肝功能仍有一定程度的下降;脂肪肝患者肝功能的改变与HDL的降低具有明显的相关性。Objective To investigate the changes of serum biochemical parameters of liver function and serum lipids in fatty liver patients and to analyze the correlations of them. Methods Physical examination data of 61 fatty liver patients compared with those of 122 normal controls which collected from the medical center of Henan provincial people＇s Hospital. Results The serum alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,total bilirubin（ TBIL）,direct bilirubin（ DBIL）,alkaline phosphatase（ ALP） and gamma glutamyl transfer enzyme（ γ-GGT） of the fatty liver patients were significantly higher than those of the normal controls,and the differences were statistically significant（ P〈0. 05）. As for lipid parameters,serum triglyceride（ TG） of fatty liver patients was significantly higher than that of normal control group,but the high density lipoprotein（ HDL） of fatty liver group was significantly lower than that of the control group（ P〈0. 05）. There were significantly positive correlations between ALT and AST,and between TBIL and DBIL（ P〈0. 05）. Significantly negative correlations were showed between HDL and serum ALT,AST,TBIL,ALP and γ-GGT（ P〈0. 05）. But no significant correlation was showed between TG and other parameters（ P〈0. 05）. Conclusion The high level of TG and the low level of HDL are relatively independent risk factors in the development of fatty liver. Although some of the fatty liver patients show no symptoms,but the liver function still decrease in some degree. Some relation maybe exist between fatty liver disease and the decreased serum HDL level.

关 键 词：脂肪肝 肝功能 血脂 氨基转移酶 高密度脂蛋白 

分 类 号：R575.5[医药卫生—消化系统]