血清NSE、CEP350、Cyfra21-1和CEA在肺癌诊断中的临床研究  

Clinical studies of serum NSE,CEP350,Cyfra21-1 and CEA in the diagnosis of lung cancer

作　　者：俞北伟 楼立新 章丽琴[1] 叶建明[1] 郭辉[1] 王瑞权[1] 

机构地区：[1]金华市人民医院,浙江金华321000

出　　处：《中国卫生检验杂志》2015年第23期4068-4070,共3页Chinese Journal of Health Laboratory Technology

基　　金：2013年度金华市科学技术研究计划项目(2013-3-059)

摘　　要：目的探讨血清神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、人中心体蛋白350k Da(CEP350)、细胞角蛋白21-1片断(Cyfra21-1)联合检测对肺癌的诊断价值。方法检测252例肺癌住院患者(观察组)、160例良性肺疾病患者(良性肺疾病组)、健康体检者(对照组)血清NSE、CEP350、Cyfra21-1和CEA水平。结果肺癌组血清NSE、CEA、Cyfra21-1和CEP350水平均明显高于良性肺疾病组和对照组,差异均有统计学意义(F值分别为66.756、802.082、63.509、539.375,P<0.01)。血清NSE、CEP350、Cyfra21-1和CEA单项检测中,对肺癌的灵敏度由高到低依次为CEA、CEP350、NSE、Cyfra21-1;4种肿瘤标记物对肺癌的特异度比较,差异无统计学意义(P>0.05)。血清NSE、CEA、Cyfra21-1和CEP350联合检测时,诊断灵敏度高达96.8%。结论血清NSE、CEP350、Cyfra21-1和CEA均可作为早期肺癌的诊断指标,联合检测意义更大。Objective To investigate the diagnostic value of combined detection of serum neuron-specific enolase（ NSE）,carcinoembryonic antigen（ CEA）,human centrosome protein 350 k Da（ CEP350）,cytokeratin fragment 21-1（ Cyfra21-1） in the diagnosis of lung cancer. Methods 252 cases of hospitalized patients with lung cancer were set as observation group,160 patients with benign lung diseases were set as benign lung disease group and 100 cases healthy subjects were set as control group,then,serum NSE,CEP350,Cyfra21-1 and CEA levels of them were detected. Results Serum NSE,CEA,Cyfra21-1 and CEP350 in the lung cancer group were significantly higher than that in the benign lung disease group and the control group,and the differences were statistically significant（ F = 66. 756,802. 082,63. 509,539. 375,P〈0. 01）. The individual detection showed that the susceptibility of serum NSE,CEP350,Cyfra21-1 and CEA to lung cancer was in a descending order of CEA,CEP350,NSE and Cyfra21-1; the differences on specification in the 4 kinds of tumor markers for lung cancer were statistically significant（ P〈0. 05）. The diagnostic sensitivity reached to 96. 8% in the combined detection of NSE,CEA,Cyfra21-1 and CEP350. Conclusion Serum NSE,CEP350,Cyfra21-1 and CEA can be used as an early diagnostic marker for lung cancer,but the combined detection is of greater significance.

关 键 词：神经元特异性烯醇化酶 癌胚抗原 人中心体蛋白 细胞角蛋白21-1片断 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]