Rsf-1在肝细胞癌中的表达及意义  

The expression and significance of Rsf- 1 in hepatocellular carcinoma

作　　者：张秀伟[1] 徐慧慧[1] 高祁[1] 姜洪磊[1] 李庆昌[2] 

机构地区：[1]中国医科大学附属第四医院,辽宁沈阳110032 [2]中国医科大学基础医学院病理教研室,辽宁沈阳11000

出　　处：《现代肿瘤医学》2016年第1期98-100,共3页Journal of Modern Oncology

摘　　要：目的:分析Rsf-1在肝细胞癌中的表达及其与临床病理因素间的关系。方法:应用免疫组化方法检测肝细胞癌中Rsf-1的蛋白表达情况。结果:免疫组化结果显示43.1%(28/65)的病例存在Rsf-1蛋白的过表达,其过表达与肝癌患者的年龄、性别、肝炎、肝硬化和淋巴结转移等未发现有明显的相关性,而与肝细胞癌的术前AFP值和高p-TNM分期呈正相关(P=0.026;P=0.041)。结论:肝细胞癌中存在Rsf-1蛋白的高表达,并与术前AFP值和高p-TNM分期相关。Objective：To study the expression of Rsf - 1 in hepatocellular carcinoma and the relationship between its expression and clinical pathological factors. Methods：Immuuohistochemical method was employed to evaluate protein levels of Rsf - 1 in hepatocellular carcinoma. Results： Rsf - 1 expression was observed in the nuclear compartments of tumor cells, while normal liver tissues exhibited negative or weak expression. For 65 hepatocellular carcinoma tissues,negative and weak Rsf - t expression （ score 〈 3 ） was observed in 56.9% （ 37/65 ） of cases, while Rsf - 1 overexpression （score i〉3） was observed in 43.1% cases （28/65）. There was no statistical difference between Rsf - 1 overexpression and age （ P = 0.526 ）, gender （ P = 0. 230 ） , hepatitis （ P = 0. 835 ） , cirrhosis （ P = 0. 447 ） , and nodal status （P = 0. 942 ）. Strong Rsf- 1 expression correlated with high serum AFP levels （P = 0.026 ） and patients with high Rsf - 1 expression had advanced stage of hepatocellular carcinoma （P = 0.041 ）. Conclusion：There was ex- pression of Rsf - l in hepatocellular carcinoma. Strong Rsf - 1 expression correlated with serum AFP levels and patients with high Rsf - 1 expression had advanced stage of hepatocellular carcinoma.

关 键 词：染色质重塑因子 肝细胞癌 免疫组织化学 

分 类 号：R735.7[医药卫生—肿瘤]