参麦注射液辅助化疗对恶性肿瘤患者急性时相蛋白及细胞免疫功能的影响  

Effects of Shenmai Injection(参麦注射液) Combining with Chemotherapy on Acute Phase Proteins and Cellular Immunity in Malignant Tumor Patients

作　　者：吴贞[1] 丁纪元[1] 沈虹[2] 于卓[2] 

机构地区：[1]浙江省杭州市肿瘤医院,杭州310002 [2]浙江大学医学院附属第二医院,杭州310009

出　　处：《中国中医药科技》2015年第6期611-613,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：浙江省教育厅应用研究一般项目(Y201225004)

摘　　要：目的:观察参麦注射液辅助化疗对恶性肿瘤患者急性时相蛋白和免疫细胞的影响。方法:选取恶性肿瘤患者41例,随机分为两组,参麦注射液组(参麦组)21例,对照组20例。治疗2个周期后对其疗效、KPS改变、毒副作用进行评价,并观察治疗前后急性时相蛋白、免疫功能等指标的变化。结果:参麦组有效率为52.4%,略优于对照组40.0%,但无统计学意义(P>0.05);参麦组的KPS评分改善明显优于对照组;参麦组Ⅲ度以上白细胞下降、恶心呕吐、肝功能异常、静脉炎的发生率明显低于对照组;治疗后参麦组铜蓝蛋白及触珠蛋白水平明显低于对照组(P均<0.05),CRP变化无统计学意义。参麦组治疗后CD+3、CD+4、NK细胞比率、CD+4/CD+8比值均有所升高,与对照组比较具有显著性意义(P<0.01)。结论:参麦注射液可增强患者细胞免疫功能,减轻急性炎症反应,从而增强化疗疗效,提高患者的生存质量,减轻毒副反应。Objective： To investigate the effects of Shenmai Injection combining with chemotherapy on acute phase proteins and cellular imniunity in malignant tumor patients. Methods： 41 patients with malignant tumor were randomly divided into two groups. 21 cases were treated with Shenmai Injection combined with chemotherapy,20 cases with chemotherapy,alone. Curative effect,KPS,toxicity were carried out after 2 cycles of therapy,acute phase proteins,immune function were observed before and after treatment. Results： The effective rate of Shenmai group was 45. 8%,that was slightly better than that of the control group（ 40%）（ P〈0. 05）. The improvement of KPS in Shenmai group was significantly better than that in the control group. The incidence of severe leucopenia,nausea and vomiting,liver dysfunction and phlebitis of the Shenmai group were significantly lower than those of control group. After the treatment,the levels of ceruloplasmin and haptoglobin of the Shenmai group were significantly lower than those in the control group（ P〈0. 05）. There was no significant difference in the level of CRP. The levels of CD＋3,CD＋4,NK,CD＋4/ CD＋8ratio were increased after the treatment and there was significant differences comparing with the control group（ P〈0. 01）. Conclusion： Shenmai Injection can enhance the cellular immunity and relieve acute inflammation reaction,thereby enhance efficacy of chemotherapy,improves the quality of life of patients and reduce adverse reactions.

关 键 词：肿瘤 参脉注射液 @急性时相蛋白 T淋巴细胞 

分 类 号：R730.53[医药卫生—肿瘤]