全反式维甲酸对急性早幼粒细胞白血病患者血清学的影响  

Effect of All-trans Retinoic Acid in Acute Promyelocytic Leukemia Patients with Serologically

作　　者：高晓艳[1] 李雨遥[2] 吕润林 田小清[1] 刘梅[1] 

机构地区：[1]陕西省榆林市第二医院血液内科,陕西榆林719000 [2]西安交通大学第一附属医院肿瘤科,陕西西安710061

出　　处：《现代生物医学进展》2015年第34期6756-6758,6800,共4页Progress in Modern Biomedicine

基　　金：陕西省科技攻关项目(2005-K-G4)

摘　　要：目的:探讨全反式维甲酸(All trans retinoic acid,ATRA)作为辅助剂在急性早幼粒细胞白血病(Acute promyelocytic leukemia,APL)治疗中,对患者血清促红细胞生成素(Erythropoietin,EPO)、血清铁蛋白、叶酸和维生素B12水平的影响。方法:回顾性分析我院2011年6月-2015年6月接诊的50例急性早幼粒细胞白血病患者的临床资料。根据患者的治疗方法不同将患者分为两组,A组(亚砷酸钠治疗组)和B组(亚砷酸钠联合ATRA)。对比两组患者治疗后血清铁蛋白、EPO、叶酸和维生素B12恢复情况。结果:两组患者入院时所有血清EPO、铁蛋白等比较,差异无统计学意义(P>0.05);治疗后两组患者血清各指标均有所改善(P<0.05);治疗后B组患者中EPO、血清B12、血清铁蛋白和叶酸恢复正常水平者明显多于A组,差异具有统计学意义(P<0.05)。结论:全反式维甲酸辅助治疗急性早幼粒细胞白血病患者能够更好的改善患者血清EPO、铁蛋白、叶酸和维生素B12的异常,对于疾病的治疗有一定的效果。Objective： To investigate the effect of all-trans retinoic acid （ATRA） as adjuvant treatment on the level of serum erythropoietin （Erythropoietin, EPO）, ferritin, folic acid and vitamin BI2 in the patients with acute promyelocytic leukemia （APL）. Methods： All clinical data of 50 cases with APL - were retrospective collected in our hospital from June 2011 to June 2015. According to the different treatment methods, all the patients were divided into two groups, group A, and B. The level of serum ferritin, EPO, folic acid and vitamin B12 was compared between two groups after treatment. Results： There was no significant difference between the two groups of in the level of serum EPO and ferritin before treatment （P〉0.05）; after treatment, the level of each index was obviously improved （P 〈0.05）. The case number that the serum EPO, ferritin, folic acid and vitamin B12 returned to normal level in group B was more than that of group A, all had statistically significant difference, P〈0.05. Conclusions： All-trans retinoic acid can improve the abnormality of serum EPO, ferritin, folic acid and vitamin B12 in the adjuvant treatment of patients with APL, and has a certain curative effect for this disease.

关 键 词：急性早幼粒细胞白血病 全反式维甲酸 促红细胞生成素 铁蛋白 叶酸 

分 类 号：R733.71[医药卫生—肿瘤]