Correlat ion of thiamine metabolite levels with cognitive function in the non-demented elderly  

作　　者：Jingwen Lu Xiaoli Pan Guoqiang Fei Changpeng Wang Lei Zhao Shaoming Sang Huimin Liu Meng Liu Hui Wang Zhiliang Wang Chunjiu Zhong 

机构地区：[1]Department of Neurology,Zhongshan Hospital and Shanghai Medical College,Fudan University [2]State Key Laboratory of Medical Neurobiology and Institutes of Brain Science,Fudan University [3]Regional Health Service Center of Xujiahui

出　　处：《Neuroscience Bulletin》2015年第6期676-684,共9页神经科学通报（英文版）

基　　金：supported by the National Basic Research Development Program (973 Program) of China (2011CBA00400);the National Natural Science Foundation of China (91332201);the Natural Science Foundation of Shanghai Municipality, China (13JC1401501);the Fund for Medical Emerging Cutting-edge Technology of Shanghai Municipality, China (SHDC12012114)

摘　　要：Thiamine metabolism is critical for glucose metabolism and also vital for brain function, which is susceptible to decline in the elderly. This study aimed to investigate whether thiamine metabolites correlate with cognitive function in the non-demented elderly and their impact factors. Volunteers 〉60 years old were recruited and their blood thiamine metabolites and Mini-Mental State Examination （MMSE） scores were measured. The apolipoprotein E （APOE） genotype, routine blood parameters, liver and kidney function, and levels of fasting blood glucose and triglycerides were also measured. The results showed that the thiamine diphosphate （TDP） level weakly correlated with MMSE score in the non-demented elderly. Participants with high TDP levels performed better in Recall and Attention and Calculation than those with low TDP. TDP levels were associated with the APOE E2 allele, body mass index, hemoglobin level, fasting blood glucose, and triglycerides. Our results suggest that TDP, which is easily affected by many factors, impacts cognitive function in the elderly.Thiamine metabolism is critical for glucose metabolism and also vital for brain function, which is susceptible to decline in the elderly. This study aimed to investigate whether thiamine metabolites correlate with cognitive function in the non-demented elderly and their impact factors. Volunteers 〉60 years old were recruited and their blood thiamine metabolites and Mini-Mental State Examination （MMSE） scores were measured. The apolipoprotein E （APOE） genotype, routine blood parameters, liver and kidney function, and levels of fasting blood glucose and triglycerides were also measured. The results showed that the thiamine diphosphate （TDP） level weakly correlated with MMSE score in the non-demented elderly. Participants with high TDP levels performed better in Recall and Attention and Calculation than those with low TDP. TDP levels were associated with the APOE E2 allele, body mass index, hemoglobin level, fasting blood glucose, and triglycerides. Our results suggest that TDP, which is easily affected by many factors, impacts cognitive function in the elderly.

关 键 词：thiamine diphosphate cognitive function non-demented elderly 

分 类 号：R749[医药卫生—神经病学与精神病学]