自噬-非酒精性脂肪肝病的治疗新靶向  

Autophagy,a new target for non-alcoholic fatty liver disease therapy

作　　者：毛雨晴 樊晓明[1] 

机构地区：[1]复旦大学附属金山医院消化内科,上海市201508

出　　处：《世界华人消化杂志》2015年第32期5107-5112,共6页World Chinese Journal of Digestology

基　　金：上海市卫生局基金资助项目;No.2010075;上海市自然科学基金资助项目;No.11ZR1405700;上海市医学重点专科建设计划基金资助项目;N o.ZK2012B20~~

摘　　要：随着饮食结构和生活方式的改变,非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)在人类肝病谱中,占据越来越重要的地位.NAFLD经历由单纯脂肪变性,脂肪性肝炎、肝纤维化甚至肝癌的自然病程.虽然NAFLD的分子机制已经被深入研究,但目前仍缺乏有效的药物治疗方法.自噬作为一种细胞内的自我保护机制,能将细胞内损伤或多余的细胞成分进行自我消化,并为细胞器重新合成提供物质和能量循环的过程,可能在多种疾病的发生,发展及治疗中起到重要作用.研究表明,自噬与NAFLD密切相关.但是自噬是一把双刃剑,目前与NAFLD的关系仍存在争议.The importance of non-alcoholic fatty liver disease（NAFLD） has increased among human liver diseases with the change of diet structure in recent decades worldwide.NAFLD occurs as a spectrum from simple hepatic steatosis,steatohepatitis to cirrhosis,and even hepatocellular carcinoma.Although the molecular mechanisms of NAFLD have been intensively investigated,effective therapeutic methods are still lacking.Autophagy is a cell survival mechanism for self-digesting excess or defective organelles,which are used for materials and energy recycling.Recent studies have revealed that autophagy is closely linked to NAFLD.Autophagy reduces intracellular lipid droplets by enclosing them and fusing with lysosomes for degradation.Furthermore,autophagy is involved in attenuating inflammation and fibrosis,even hepatoma.However,autophagy is regarded as a doubleedged sword,and the relationship between autophagy and NAFLD is controversial.

关 键 词：非酒精性脂肪肝病 自噬 单纯脂肪变性 脂肪性肝炎 肝纤维化 肝癌 

分 类 号：R575.5[医药卫生—消化系统]