Oral administration of hyperoxygenated solution for the prophylaxis of gastric ulceration induced by stress or Helicobacter pylori  

作　　者：MA Hong-Wei WU Ya-Qiong ZHANG Hai-Feng 

机构地区：[1]Experiment Teaching Center, School of Basic Medicine, Fourth Military Medical University [2]School of Life Sciences,Shaanxi Normal University

出　　处：《医学争鸣》2015年第6期28-34,共7页Negative

基　　金：Supported by the National Natural Science Foundation of China(81270330)

摘　　要：Oxygen was first discovered by Sweden chemist Scheele in 1773 and convinced as an essential factor for living by French scientists in 1777.To tackle with different hypoxic emergencies,corresponding medical approaches,e.g.mask or nasal catheter oxygen inhalation,breathing machine,hyperbaric oxygen therapy etc.,have been contrived in succession.However,one mortal trouble exists in all these conventional ways,i.e.they must rely on the ventilation and gas exchange via lungs,thus not being able to promptly render oxygen to specific hypoxia tissues.Hyperoxygenated solution(HOS),a new kind of medical liquid which can be orally taken or intravenously administrated,has been widely applied as an auxiliary method of offering oxygen in China.A large number of experiments have proved its validity in the treatment of myocardial and cerebral ischemia/reperfusion injury,nerve lesions,shock,respiratory diseases,neonatal hypoxia and so forth.These findings suggest that HOS might not only play a role of increasing oxygen pressure in local region,but also conspicuously contribute to improving the pathologic process of hypoxia,which coincidently is the vital link in stress-induced lesions in the gastrointestinal tract.Additionally,Helicobacter pylori(H.pylori),a kind of microaerophilic(anaerobic)bacterium which can hardly survive in an aerobic atmosphere,has also been identified as an independent risk factor for the occurrence and development of ulceration.Considering the etiology of peptic ulceration and the features of HOS,we hypothesize that drinking HOS might prevent gastric ulceration caused by stress or anaerobic H.pylori.Oxygen was first discovered by Sweden chemist Scheele in 1773 and convinced as an essential factor for living by French scientists in 1777. To tackle with different hypoxic emergencies, corresponding medical approaches, e.g. mask or nasal catheter oxygen inhalation, breathing machine, hyperbaric oxygen therapy etc., have been contrived in succession. However, one mortal trouble exists in all these conventional ways, i.e. they must rely on the ventilation and gas exchange via lungs, thus not being able to promptly render oxygen to specific hypoxia tissues. Hyperoxygenated solution （HOS）, a new kind of medical liquid which can be orally taken or intravenously administrated, has been widely applied as an auxiliary method of offering oxygen in China. A large number of experiments have proved its validity in the treatment of myocardial and cerebral isehemia/reperfusion injury, nerve lesions, shock, respiratory diseases, neonatal hypoxia and so forth. These findings suggest that HOS might not only play a role of increasing oxygen pressure in local region, but also conspicuously contribute to improving the pathologic process of hypoxia, which coincidently is the vital link in stress-induced lesions in the gastrointestinal tract. Additionally, Helicobacter pylori （H. pylori）, a kind of microaerophilic （anaerobic） bacterium which can hardly survive in an aerobic atmosphere, has also been identified as an independent risk factor for the occurrence and development of ulceration. Considering the etiology of peptic ulceration and the features of HOS, we hypothesize that drinking HOS might prevent gastric ulceration caused by stress or anaerobic H. pylori.

关 键 词：hyperoxygenated solution gastric ULCERATION PROPHYLAXIS STRESS HELICOBACTER PYLORI 

分 类 号：R573[医药卫生—消化系统]