核因子E2相关因子2对心肌缺血再灌注损伤的保护作用研究进展  

Progress of the cardioprotective role of nuclear factor erythroid 2-related factor 2 in myocardial ischemia reperfusion injury

作　　者：郭朝晖[1,2,3] 颜苗[1,2] 张毕奎[1,2,3] 

机构地区：[1]中南大学湘雅二医院药学部,长沙410011 [2]中南大学临床药学研究所,长沙410011 [3]中南大学药学院,长沙410011

出　　处：《中国临床药理学杂志》2015年第23期2366-2369,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81202975)

摘　　要：核因子E2相关因子2(Nrf2)是体内最重要的抗氧化应激防御系统的核心转录因子,其所介导的Nrf2/ARE通路能够调控一系列体内抗氧化酶、Ⅱ相解毒酶和转运蛋白表达,维持细胞内外氧化还原平衡。近年来研究发现,Nrf2在心肌缺血再灌注损伤(MIRI)发生发展中发挥着重要作用,激活Nrf2从而增强机体抗氧化能力,能在一定程度上保护心肌,减轻缺血再灌注损伤,有望成为治疗MIRI的新靶点。因此,本文综述了Nrf2对MIRI的保护作用研究进展,以期为临床治疗MIRI提供新的思路。Nuclear factor erythroid 2- related factor 2（ Nrf2） is a key transcriptional factor of endogenous antioxidant defense system,which maintains the redox balance by mediating Nrf2 / ARE pathways that could regulate the expression of a battery of downstream antioxidant enzymes,phase Ⅱdetoxifying enzymes and transport proteins. Recent studies have demonstrated that Nrf2 plays a significant role in the pathogenesis of myocardial ischemia reperfusion injury（ MIRI）,thus activation of Nrf2 lead to the increase of antioxidant capacity,and eventually alleviates myocardial injury as well as exerts cardioprotection effect to some extent,which makes it a novel promising therapeutic target. Therefore,this paper reviews the research progress of the cardioprotection effect of Nrf2 in MIRI,attempting to provide innovative ideas about treatment for MIRI in clinical practice.

关 键 词：核因子E2相关因子2 心肌缺血再灌注损伤 氧化应激 保护作用 

分 类 号：R363.21[医药卫生—病理学] R972[医药卫生—基础医学]