血管生成素与tRNA片段化  

Angiogenin Mediated t RNA Fragmentation

作　　者：付汉江[1] 郑晓飞[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所放射生物学北京市重点实验室,北京100850

出　　处：《中国生物化学与分子生物学报》2015年第12期1242-1246,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.31070702;31370760;31270836)~~

摘　　要：t RNA主要功能是转运氨基酸参与蛋白质合成,在蛋白质生物合成过程中起着关键性的作用.近年来发现,t RNA是细胞内小RNA分子的重要来源,具有其它重要的生物学功能.来源于成熟t RNA分子的t RNA片段根据切割位置及生成机制的不同,主要分为两类:一类是t RNA半分子(t RNA halves);另一类是较小的t RNA片段,称为t RFs(t RNA fragments).在哺乳动物细胞中,t RNA半分子由血管生成素在t RNA分子反密码环处切割生成.本文主要针对t RNA半分子的加工机制、功能及在临床上的潜在应用进行综述.Transfer RNAs （tRNAs） are key components of translation by transferring amino acids to the polypeptide chains during protein synthesis at the ribosomes in the cell cytoplasm. In recent years, many other important biological functions of tRNAs have been discovered, especially as an important source of small cellular RNA molecules. These small RNAs can be divided into two main categories based on the cleavage position and the mechanism of generation： tRNA halves or smaller segments tRFs （tRNA fragments）. In mammalian ceils, the tRNA halves are cleaved by angiogenin at the anticode loop of tRNAs. In this review, the processing mechanism, functions and potential clinical application of tRNA halves were discussed.

关 键 词：血管生成素 TRNA tRNA半分子 

分 类 号：Q522[生物学—生物化学]