手术对胃肠恶性肿瘤患者免疫功能的影响  

Effects of surgery on immune function in patients with gastrointestinal cancer

作　　者：吉美霞[1] 陈卫昌[2] 

机构地区：[1]苏州大学附属第一医院急诊内科,江苏省215006 [2]苏州大学附属第一医院消化病科,江苏省215006

出　　处：《江苏医药》2015年第23期2803-2805,共3页Jiangsu Medical Journal

摘　　要：目的探讨手术对胃肠恶性肿瘤患者免疫功能的影响。方法胃肠恶性肿瘤患者37例(A组),采用流式细胞仪检测外周血CD25^+、CD28^+、诱导共刺激分子(ICOS)和程序性死亡分子1(PD^(-1))的表达,与23例健康体检者(B组)比较。A组中的13例接受了肿瘤根治术。结果A组CD25~^+、CD28^+、ICOS和PD^(-1)表达水平均低于B组(P<0.05)。与术前相比,13例患者术后外周血CD25^+和CD28^+的表达水平升高(P<0.05),而ICOS和PD^(-1)表达水平手术前后无统计学差异(P>0.05)。结论胃肠恶性肿瘤患者免疫功能明显降低,手术切除肿瘤可改善患者的免疫功能。Objective To investigate the effects of surgery on the immune function in the patients with gastrointestinal cancer .Methods Serum levels of CD25^＋ ,CD28^＋ ,inducible co‐stimulator（ICOS） and programmed cell death‐1（PD‐1） in peripheral blood were detected by flow cytometry in 37 patients with gastrointestinal cancer（group A） and 23 healthy people（group B） .Of group A ,13 cases underwent radical surgery .Results Serum levels of CD25^＋ ,CD28^＋ ,ICOS and PD‐1 in peripheral blood were significantly lower in group A than those in group B （ P〈0 .05 ） . Compared to before ,serum levels of CD25^＋ and CD28^＋ were significantly elevated after operation （P〈0 .05） ,but the expressions of ICOS and PD‐1 were not significantly changed （ P〉0 .05 ） . Conclusion The immune function of patients with gastrointestinal cancer is significantly reduced , which is effectively improved after resection of gastrointestinal cancer .

关 键 词：胃肠恶性肿瘤 免疫功能 

分 类 号：R735[医药卫生—肿瘤]