调节性T细胞在急性白血病中的研究进展  

Research progress of regulatory T cell in acute leukemia

作　　者：王冬娇[1] 仇红霞[1] 

机构地区：[1]江苏省人民医院血液科、南京医科大学第一附属医院,210029

出　　处：《国际输血及血液学杂志》2015年第6期526-529,共4页International Journal of Blood Transfusion and Hematology

基　　金：国家自然科学基金（81070456,81270652）;江苏省“六大高峰人才”项目（2010-WS-019）

摘　　要：调节性T细胞（Treg）是一类具有免疫抑制功能的细胞群体,其主要作用是维持机体自身免疫耐受及调控对外来抗原的免疫应答,且在急性白血病细胞免疫逃逸中发挥重要作用.Treg与急性白血病的病程进展、治疗反应及预后相关.现就Treg的分类,Treg在急性白血病患者中的数量和功能的变化及常用化疗药物对Treg的影响进行综述.Regulatory T cell （Treg） is a subclass of immunosuppressive T cell,and the main function is to maintain immune tolerance and regulate of immune response to foreign antigens.Treg also plays an important role in immune escape of leukemia cells.Currently,more and more studies prove that Treg is related to leukemia progression,treatment response and prognosis,therefore regulation of Treg may become a part of acute leukemia immunotherapy.This review focuses on the classification,number and functionality of Treg in acute leukemia patients as well as the impact of chemotherapy drugs on Treg.

关 键 词：白血病 急性 T淋巴细胞 调节性 免疫 

分 类 号：R733.71[医药卫生—肿瘤]