多发性骨髓瘤诊断标准的更新：2015年国际骨髓瘤工作组会议报道  

Updated diagnostic criteria for multiple myeloma： report from 2015 International Myeloma Working Group conference

作　　者：朱婉秋[1] 陈文明 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100020 [2]北京多发性骨髓瘤医疗研究中心,北京100020

出　　处：《国际输血及血液学杂志》2015年第6期554-556,共3页International Journal of Blood Transfusion and Hematology

基　　金：国家自然科学基金（81172252）

摘　　要：随着对多发性骨髓瘤（MM）生物学特性了解的不断深入,治疗方案的多样化,以及实验室和影像学技术的不断进步,国际骨髓瘤工作组（IMWG）在2014年对MM诊断标准进行了修订.2015年,IMWG在维也纳召开会议,对修订后的MM诊断标准进行解读和讨论.并对活动性MM重新进行了定义,即骨髓克隆性浆细胞比例≥10％和（或）活组织病理学检查证实为浆细胞瘤;同时伴有以下一种或多种情况：高钙血症、肾功能不全、贫血和溶骨性骨损害;将骨髓克隆性浆细胞比例≥60％、受累血清游离轻链与未受累血清游离轻链比值≥100、MRI检查发现局灶性病变部位＞1处（每处检查的病灶直径≥5 mm）作为极高危无症状MM生物学标志物纳入MM诊断标准.With deep understanding of the biological characteristics of multiple myeloma （MM）,treatment diversity,and the improvement of laboratory and imaging technology,the International Myeloma Working Group （IMWG） revised the diagnostic criteria for MM in 2014 and held a conference in Vienna in 2015.In this conference,experts made an interpretation and discussion for the revised diagnostic criteria for MM.Redefined active MM as proportion of clonal bone marrow plasma cells ≥ 10% or biopsy-proven plasmacytoma and any one or more of the following conditions.Sypercalcaemia,renal insufficiency,anemia and osteolytic bone destruction;super high risk smoldering myeloma biomarkers including proportion of clonal bone marrow plasma cells ≥60 %,a serum involved to uninvolved free light chain ratio ≥100,and 〉 1 focal lesions on MRI （each focal lesion must be 5 mm or more in size） were included in the MM diagnostic criteria.

关 键 词：多发性骨髓瘤 诊断 

分 类 号：R733.3[医药卫生—肿瘤]