早期泼尼松联合阿昔洛韦治疗Bell麻痹的疗效观察  

Efficacy of Early Treatment of Bell's Plasy With Prednisone and Acyclovir

作　　者：陶涛[1] 杨军[2] 秦新月[2] 李倩[3] 

机构地区：[1]泸州医学院附属医院神经内科,四川泸州646000 [2]重庆医科大学附属第一医院神经内科,重庆400016 [3]重庆市第五人民医院神经内科,重庆400061

出　　处：《四川医学》2015年第11期1536-1538,共3页Sichuan Medical Journal

摘　　要：目的比较单用泼尼松与泼尼松联合阿昔洛韦治疗急性期Bell麻痹的疗效。方法 164例发病时间在72h以内的Bell麻痹患者。其中,单纯泼尼松治疗组79例,泼尼松联合阿昔洛韦治疗组85例。以House-Brackmann分级法作为治疗后3个月面神经功能的评估标准。结果治疗3个月后,泼尼松联合阿昔洛韦治疗组面瘫完全恢复率为87.1%,略高于单用泼尼松组的84.8%(=0.024,P>0.05)。入院时严重瘫痪的患者,联合治疗组面瘫完全恢复率为85.5%,单用泼尼松治疗完全恢复率为81.8%,两组间比较差异无统计学意义(=0.313,P>0.05)。结论早期泼尼松联合阿昔洛韦治疗Bell麻痹疗效并不优于单用泼尼松治疗组。Objective To compare the therapeutic efficacy of prednisolone alone to acyclovir plus prednisolone in patients with acute idiopathic facial palsy. Methods Using a prospective design. A total of 164 patients suffering from Bell＇s plasy within72 hours after the onset of symptoms were divided into prednisolone group（ n = 79） and prednisolone plus acyclovir group（ n = 85） .The demographic data and clinical characteristics in both groups were collected. Facial nerve function outcomes were evaluated 3months after the onset with House-Brackmann grading system. Results The proportions of patients who had completely recovered at 3 months in prednisolone plus acyclovir group were slightly higher than that in the prednisolone group（ 87. 1% vs 84. 8%, =0. 024,P 〉0. 05）. Patients with severe plasy,the recovery rate that treated with prednisolone plus acyclovir and prednisolone alone were 85. 5% and 81. 8%,respectively. There was no significant difference（ = 0. 313,P 〉0. 05）. Conculsion Patients with Bell＇s palsy,early treatment with prednisolone in combination with acyclovir is no better than the single treatment with prednisolone.

关 键 词：贝尔麻痹 泼尼松 阿昔洛韦 疗效 

分 类 号：R745.12[医药卫生—神经病学与精神病学]