长春瑞滨联合顺铂治疗中晚期乳腺癌的临床效果及不良反应观察  

The clinical effect and adverse reaction of Changchun vinorelbine combined with cisplatin in the treatment of breast cancer

作　　者：汪志春[1] 张利群[1] 徐胜昔[1] 

机构地区：[1]江西省九江市第一人民医院乳腺外科,332000

出　　处：《临床合理用药杂志》2015年第35期16-17,44,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨长春瑞滨联合顺铂治疗中晚期乳腺癌的临床效果及不良反应发生情况。方法选取2012年1月-2015年1月医院收治的中晚期未行手术治疗的乳腺癌患者72例,根据入院先后分为对照组与观察组各36例。对照组给予顺铂、叶酸钙、5-氟尿嘧啶治疗,观察组给予长春瑞滨联合顺铂治疗,比较2组治疗效果及不良反应发生情况。结果观察组治疗总有效率为83.3%明显高于对照组的63.9%,差异有统计学意义(P<0.05)。观察组恶心、呕吐发生率明显高于对照组,差异有统计学意义(P<0.05);2组静脉炎、脱发、贫血、白细胞降低、血小板降低、肝肾功能异常的发生率比较差异无统计学意义(P>0.05)。结论长春瑞滨联合顺铂治疗乳腺癌的临床效果显著,可有效提升治疗效果,除胃肠道不良反应有所增加外,其余不良反应未见增加,临床治疗时应联合止吐药使用,以提高患者的耐受性。Objective The incidence of clinical effects and adverse reactions of vinorelbine combined with cisplatin in the treatment of breast cancer. Methods 72 patients with advanced breast cancer who had not received surgical treatment, according to the order of admission, divided into control group and treatment group, 36 cases in each group. The control group was treated with cisplatin, calcium Folinate-SF and 5-fluorouracil. The observation group was given Changchun vinorelbine com- bined with cisplatin in the treatment. The efficacy and adverse reactions of the 2 groups were compared. Results The total ef- fective rate of the observation group was 83.3% which was significantly higher than that of 63.9% in the control group （P 〈 0. 05 ） ;The incidence of nausea and vomiting in the observation group was significantly higher than that in the control group, the difference was statistically significant （ P 〈 0.05 ） ; Two groups of phlebitis, alopecia, Anemia, white blood cells and platelets decreased, abnormal function of the liver and kidney rate was no significant difference （ P 〉 0.05 ）. Conclusion The clinical effect of Changchun vinorelbine combined with cisplatin in the treatment of breast cancer was significantly, can effectively im- prove the treatment effect. In addition to the adverse reaction of gastrointestinal tract, the other adverse reactions were not in- creased. Clinical treatment should be combined with the use of antiemetic drugs ,in order to improve the tolerance of patients.

关 键 词：乳腺癌 中晚期 长春瑞滨 顺铂 不良反应 

分 类 号：R737.9[医药卫生—肿瘤]