代谢综合征与胆囊结石的相关性研究  

Association between metabolic syndrome and gallstone disease

作　　者：陈建华[1] 乔巧华[1] 朱文华[1] 方力争[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院全科医学科,浙江杭州310016

出　　处：《全科医学临床与教育》2015年第6期632-634,共3页Clinical Education of General Practice

基　　金：浙江省教育厅科研项目(Y201223481)

摘　　要：目的 探讨代谢综合征与胆囊结石发生的的相关性. 方法 采用横断面研究的方法,选择本院体检中心体检人群7 570例,918例有胆囊结石作为研究组,6 652例无胆囊结石者作为对照组,观察两组腰围、血压、空腹血糖、血脂等指标,并分析代谢综合征与胆囊结石之间的相关性.结果 研究组人群的腰围、收缩压、舒张压、空腹血糖、 甘油三酯水平均高于对照组, 但高密度脂蛋白胆固醇水平低于对照组, 差异均有统计学意义 （t分别=2.29、2.96、2.21、2.27、3.14、1.99,P均〈0.05）.经校正年龄后,代谢综合征与胆囊结石形成相关（OR=1.42,95%CI 为1.23~1.64）. 结论 代谢综合征与胆囊结石有很强的关联.Objective To investigate the association between metabolic syndrome and the development of gallstone dis-ease. Methods A cross-sectional study was conducted in 7570 subjects enrolled from the physical check-up center of the hospital. The subjects included 918 patients with gallstones and 6652 healthy controls without gallstones. The waist circum-ference, blood pressure, fasting blood-glucose and serum lipids were measured and the relationship between metabolic syndrome and gallstone disease was analyzed. Results Waist circumference, systolic blood pressure, diastolic blood pres-sure, fasting blood-glucose and serum triglyceride in patients with gallstones were significantly higher than those in con-trols while the serum high-density lipid was significantly lower than control group （t=2.29, 2.96, 2.21, 2.27, 3.14, 1.99, P〈0.05）. After age adjusting, the metabolic syndrome showed the serious relation with gallstone （OR=1.42, 95%CI1.23--1.64）. Conclusions The metabolic syndrome is seriously relate with gallstone.

关 键 词：胆囊结石 肥胖 高血压 血脂异常 代谢综合征 

分 类 号：R589[医药卫生—内分泌] R575.62[医药卫生—内科学]