艾司西酞普兰与舍曲林治疗门诊广泛性焦虑的疗效比较  

Effect of escitalopram and sertraline on generalized anxiety disorder in outpatient

作　　者：袁国锋[1] 俞玉礼 

机构地区：[1]杭州市公安局安康医院精神科,浙江杭州311113 [2]杭州市余杭区仓前镇社区卫生服务中心

出　　处：《全科医学临床与教育》2015年第6期649-651,共3页Clinical Education of General Practice

摘　　要：目的探讨艾司西酞普兰和舍曲林治疗门诊广泛性焦虑患者的临床疗效和安全性。方法选取70例广泛性焦虑患者并随机分为艾司西酞普兰组和舍曲林组,各35例,分别给予艾司西酞普兰和舍曲林治疗6周,于治疗前、治疗第1、2、4、6周末5个时间分别采用汉密尔顿焦虑量表(HAMA)、临床疗效总评量表(CGI)、药物不良反应评定量表(TESS)评估疗效和不良反应。结果两组HAMA、CGI评分在治疗后各时点均明显下降,与治疗前比较差异均有统计学意义(t分别=-4.90、-13.49、-18.44、-21.90、-13.66、-14.93、-16.17、-16.64;-1.82、-12.69、-16.55、-18.92、-1.49、-13.13、-15.39、-15.95,P均<0.05);在治疗1周末时,艾司西酞普兰组的HAMA量评分低于舍曲林组,差异有统计学意义(t=-3.89,P<0.05),而两组的CGI量表评分比较,差异无统计学意义(t=-0.25,P>0.05);在第2、4、6周末时,两组HAMA、CGI量表评分比较差异均无统计学意义(t分别=-0.59、-0.74、-1.06、-0.75、-0.64、-0.09,P均>0.05)。艾司西酞普兰组和舍曲林组显效率分别是60.00%和57.14%,有效率分别是82.86%和80.00%,两组显效率和有效率比较,差异均无统计学意义(χ2分别=0.06、0.09,P均>0.05)。两组副反应发生率比较低,差异无统计学意义(χ2=0.00,P>0.05)。结论艾司西酞普兰治疗广泛性焦虑的起效较舍曲林快,疗效和不良反应与舍曲林相似。Objective To explore the curative effect and safety of escitalopram and sertraline in the treatment of gener-alized anxiety disorder in outpatient. Methods A total of 70 patients with generalized anxiety disorder were divided into escitalopram group and sertraline group with 35 cases in each, which were given escitalopram or sertraline for 6 weeks. The hamilton anxiety scale （HAMA）, treatment emergent symptom scale （TESS）, clinical global impression （CGI） were used to evaluated clinical efficacy and adverse reactions before treatment and at first, second, fourth and sixth weekend. Results Compared with before treatment, the HAMA, CGI score of two groups at each point after treatment were signifi-cantly decreased, the differences were statistically significant（t=-4.90,-13.49,-18.44,-21.90;-13.66,-14.93,-16.17,-16.64;-1.82,-12.69,-16.55, -18.92;-1.49,-13.13,-15.39,-15.95,P〈0.05）. At first weekend, the HAMA scores of escitalopram group was significantly lower than that of sertraline group （t=-3.89,P〈0.05）, while the CGI scores between two groups had no statistical difference （t=-0.25,P〉0.05）. At second, fourth, sixth weekend, the HAMA, CGI scale scores of two groups was not statistically different （t=-0.59,-0.74,-1.06;-0.75,-0.64,-0.09,P〉0.05）. The explicit effi-ciency of escitalopram group and sertraline group were 60.00% and 57.14%, the efficiencies were 82.86% and 80.00%, but there were no statistically significant difference in explicit efficiency and efficiency between two groups（χ2=0.06, 0.09, P〉0.05）. the adverse reactions occurred in the two groups had not statistical difference （χ2=0.00,P〉0.05）. Conclusion Escitalopram is more effective than sertraline for treating generalized anxiety, but the efficacy and adverse reactions are similar to sertraline.

关 键 词：艾司西酞普兰 舍曲林 广泛性焦虑 疗效 

分 类 号：R749.72[医药卫生—神经病学与精神病学]