依达拉奉对老年短暂性脑缺血发作患者血清超氧化物歧化酶和丙二醛的影响  

Clinical Effect of edaravone on serum superoxide dismutase and malondialdehyde levels in elderly transient ischemic attack

作　　者：王欣[1] 施蝉宏 毛蓉嫣 

机构地区：[1]义乌市中心医院神经内科,322000

出　　处：《中华老年医学杂志》2015年第12期1310-1312,共3页Chinese Journal of Geriatrics

基　　金：浙江省科技计划基金（2013KYA124）

摘　　要：目的探讨依达拉奉治疗老年人短暂性脑缺血发作的临床疗效及其对血清超氧化物歧化酶（s0D）和丙二醛（MDA）水平的影响。方法选择本院收治的老年短暂性脑缺血发作患者98例，随机分为观察组和对照组各49例；观察组采用依达拉奉联合常规治疗，对照组采用常规治疗，对比分析两组患者临床疗效、血清SOD和MDA水平。结果观察组与对照组比较，治疗显效率（79．6％比55．1％，X2=6．914，P=0．008）和总有效率（95．9％比83．7％，X2=4．354，P=0．032）均明显升高，差异有统计学意义。治疗后观察组血清SOD水平明显高于对照组，MDA水平明显低于对照组（P〈0．001）。结论依达拉奉可改善老年短暂性脑缺血发作症状，提高SOD活力，降低MDA水平，有利于减少脂质过氧化物产生，减轻自由基毒害，提高机体抗氧化能力。Objective To investigate the clinical effect of Edaravone on transient ischemic attack and serum superoxide dismutase and malondialdehyde levels in the elderly. Methods Ninety eight cases with transient ischemic attack treated in our hospital were chosen as the objects, which were randomly divided into observation group and control group （n=49 for each）. Patients in observation group were treated with Edaravone combined with conventional therapy, and patients in control group were treated with conventional therapy. The clinical effect and levels of SOD and MDA were analyzed and compared between the two groups. Results The effective rate and total efficiency were higher in observation group than in control group （79.6% vs 55.1%, 95.9% vs. 83.7%, X2 =6. 914 and 4. 354, P=0. 008 and 0. 032）. The SOD level was higher and the MDA level was lower in observation group than in control group （both P〈0. 001） after treatment. Conclusions Edaravone could improve the symptoms of transient ischemic attack in the elderly, and increase the activity of SOD and reduce MDA level, which is helpful to reduce lipid peroxides, alleviate free radical toxicity, and improve the anti-oxidation ability.

关 键 词：脑缺血发作 短暂性 自由基清除剂 超氧化物歧化酶类 丙二醛 

分 类 号：R743.31[医药卫生—神经病学与精神病学]