儿茶酚氧位甲基转移酶基因多态性与中国南方人群精神分裂症的关联研究  

Association analysis of catechol-O-methyltransferase gene polymorphisms with schizophrenia in southern Chinese population

作　　者：江娟[1] 韦波[1] 龙建雄[1] 凌维俊 黄桂凤[1] 苏莉[1] 

机构地区：[1]广西医科大学公共卫生学院,南宁530021

出　　处：《中华行为医学与脑科学杂志》2015年第11期996-999,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81060244）;广西自然科学基金项目（2013GXNSFAA019352）;广西高校科学技术研究项目（2013YB043）

摘　　要：目的 探讨儿茶酚氧位甲基转移酶基因多态性与中国南方人群精神分裂症易感性及PANSS测评症状之间的关联.方法 采用Sequenom基因分型技术,在700例病例（壮族300例,汉族400例）和700例对照（壮族300例,汉族400例）中,对COMT基因rs4633 、rs4680和rs8185002进行基因分型,并采用阳性与阴性症状量表（PANSS）对患者进行症状测评.采用PLINK软件进行统计学分析.结果 分别在壮族样本、汉族样本中,这三个位点与精神分裂症易感性的关联差异无统计学意义（P＞0.05）.合并两民族样本后,rs4633（I2=0.000,Pmeta=0.040）和rs4680（I2 =0.000,Pmeta=0.014）与精神分裂症易感性的关联差异有统计学意义;单体型T-A-T与精神分裂症易感性关联（P=0.049）差异有统计学意义.三个位点多态性与PANSS总分、阳性量表分、阴性量表分和一般精神病理量表分之间的关联均差异无统计学意义（P＞0.05）.结论 COMT基因rs4633、rs4680多态性影响中国南方人群精神分裂症的发生.Objective To explore the association of catechol-O-methyhransferase（COMT） gene polymorphisms with schizophrenia susceptibility and its symptoms assessed by Positive and Negative Syndrome Scale （PANSS）in southern Chinese population.Methods COMT gene rs4633,rs4680 and rs8185002 polymorphisms were genotyped using Sequenom genotyping technology in 700 schizophrenia patients （300 Zhuang and 400 Han） and 700 healthy controls （300 Zhuang and 400 Han）,and Positive and Negative Syndrome Scale （PANSS） was used for clinical symptoms assessment of patients.Statistical analysis was performed using PLINK software.Results rs4633,rs4680 and rs8185002 polymorphisms were not significantly associated with schizophrenia susceptibility in Zhuang or Han population respectively（P〉0.05）.After merging Zhuang and Han samples,rs4633（I 2 =0.000,Pmeta =0.040） and rs4680 （I2=0.000,Pmeta =0.014） were significantly associated with the susceptibility to schizophrenia.In addition,haplotype T-A-T was significantly associated with schizophrenia susceptibility （P=0.049）.However,these three polymorphisms were not significantly associated with total score,positive scale score,negative scale score and general psychopathology scale score assessed by PANSS（P〉0.05）.Conclusion COMT gene rs4633 and rs4680 polymorphisms are involved in the susceptibility to schizophrenia in southern Chinese population.

关 键 词：精神分裂症 COMT基因 多态性 关联研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学]