抑郁症自我参照加工的功能磁共振研究  

Research progress of functional magnetic resonance imaging in self-referential processing of depression

作　　者：柳艳松[1] 赵旭东[1] 

机构地区：[1]同济大学附属东方医院临床心理科,上海200120

出　　处：《中华行为医学与脑科学杂志》2015年第11期1049-1052,共4页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的 以国内外2004～ 2014年期间公开发表的有关“抑郁症自我参照加工的脑功能磁共振”的研究文献,综述抑郁症自我参照加工的神经影像学机制,为探索抑郁症的神经机制及治疗提供新的参考.方法 2014年10月检索了PubMed、EBSCO、Ovid、Medline、Clinicalkey、万方数据库、中国知网、维普数据库、中国生物医学数据库等数据库,利用“抑郁”、“自我参照加工”或“沉思”或“自传体记忆”或“自我面孔识别”、“功能磁共振功能成像”等为检索词.结果 检索157篇,纳入分析的28篇,结果显示：①沉思、自传体记忆提取、自我面孔识别是抑郁症自我参照加工的研究范式,所涉及的神经基础主要是皮质中线结构与默认模式网络;②不管是药物治疗还是认知行为治疗,能够通过降低皮质中线结构、默认模式网络的异常激活水平,达到改善抑郁症状的目的.结论 ①皮质中线结构与默认模式网络可能是抑郁症自我参照加工的神经基础;②皮质中线结构与默认模式网络或可作为评价抑郁症治疗反应的客观指标.Objective To review the research progress of functional magnetic resonance imaging in Self -referential Processing （SRP） of patients with Depression based on the papers published from 2004 to 2014 at abroad and domestic,with an attempted to explore the neuromechanism of depression and to provide reference for treatment of depression.Methods Major online database including PubMed,EBSCO,Ovid,Medline,Clinicalkey,Wan Fang,CNKI,Cqvip,and CBM date bases were searched in Octobor 2014.The key words we used are ＂depression ＂ or ＂depressive disorder＂,＂Self-referential Processing＂ or ＂rumination＂ or ＂ autobiographical memory＂ or ＂Self-face recognition＂,＂ Functional Magnetic Resonance Inaging（tMRI） ＂ and so on.Results 28 studies were adopted in this study,findings from the study showed：①rumination,autobiographical memory （AM） retrieval,and self-face recognition（SFR） are SRP paradigms,the cortical midline structures （CMS）and default mode network （DMN） were involved in the SRP of depression.②Both medication and cognitive behavioral therapy could reduce the abnormal activation of CMS and DMN in patients with depression.Conclusioins ①Both CMS and DMN may be the neuromechanism of SRP of depression.②Both CMS and DMN may be used as objective indicators to evaluate the treatment response in patients with depression.

关 键 词：抑郁症 自我参照加工 皮质中线结构 默认模式网络 功能磁共振 

分 类 号：R749.4[医药卫生—神经病学与精神病学]