延长睡眠时间与中风风险的荟萃分析  

A meta-analysis of relative ratio of stroke with sleep duration

作　　者：何月[1] 彭巧玲[1] 周国庆[1] 

机构地区：[1]南京军区南京总医院干部神经内科,江苏南京210002

出　　处：《临床荟萃》2015年第12期1413-1416,共4页Clinical Focus

摘　　要：目的分析延长睡眠时间与中风风险,对睡眠时间延长是否增加中风风险做出循证医学分析。方法检索MEDLINE、PUBMED、EMBASE、WOS 1997-2015年相关文献,Jadad评分评估所涉及研究的质量,剔除评分小于4分的研究,取得每项研究的睡眠时间与中风风险的相对风险度（RR）值及95%可信区间（95%CI）,STATA11.0合并分析睡眠时间延长与中风风险的RR及P值,并通过分层（按性别、短暂延长睡眠时间、长时延长睡眠时间）进一步分析睡眠时间延长与中风的风险。结果延长睡眠时间（〉8小时）中风总风险增高（RR=1.28,95%CI=1.22-1.35,P=0.00）;短暂延长睡眠时间（8-10小时）中风风险增高（RR=1.15,95%CI=1.07-1.24,P=0.00）;其中未分性别研究中风风险度增高（RR=1.12,95%CI=1.00-1.24,P=0.052）;男性中风风险增高（RR=1.11,95%CI=0.95-1.29,P=0.198）;女性中风风险增高（RR=1.24,95%CI=1.09-1.43,P=0.002）。长时间延长睡眠时间（≥10小时）中风风险增高（RR=1.41,95%CI=1.32-1.52,P=0.00）;其中未分性别中风风险增高（RR=1.30,95%CI=1.17-1.45,P=0.00）;男性中风风险增高（RR=1.46,95%CI=1.29-1.66,P=0.00）;女性中风风险增高（RR=1.56,95%CI=1.36-1.78,P=0.00）。结论延长睡眠眠时间（〉8小时）中风风险发生率明显增加。Objective To assess the relationship between prolonged sleep time and stroke incidence.MethodsRelated articles（1997-2015）were searched in MEDLINE,PUBMED,EMBASE and WOS.The quality of the included studies was evaluated by the Jadad scale.The relative ratio（RR）and their 95% confidence interval were pooled.RR was evaluated by meta-analysis method.Results The total relative ratio of stroke after prolonging sleep time was increased（RR =1.28,95%CI =1.22-1.35,P =0.00）.The stroke risk ratio was increased after prolonging sleep time of 8-10hours（RR =1.15,95%CI =1.07-1.24,P =0.00）,including increased stroke risk ratio in both genders（RR =1.12,95%CI =1.00-1.24,P =0.052）,increased stroke risk ratio in male（RR =1.11,95%CI =0.95-1.29,P =0.198）and increased stroke risk ratio in female（RR =1.24,95%CI =1.09-1.43,P =0.002）.The stroke risk ratio was increased after prolonging sleep time of more than 10hours（RR =1.41,95%CI =1.32-1.52,P =0.00）,including increased stroke risk ratio in both genders（RR =1.30,95%CI =1.17-1.45,P =0.00）,increased stroke risk ratio in male（RR =1.46,95%CI=1.29-1.66,P =0.00）and increased stroke risk ratio in female（RR =1.56,95%CI =1.36-1.78,P =0.00）.Conclusion Prolonging sleep time can significantly elevate the risk of stroke.

关 键 词：卒中 睡眠 META分析 危险因素 

分 类 号：R743[医药卫生—神经病学与精神病学]