自体荧光诊断技术的研究进展及发展方向  

Recent Research Progress and Development Direction of Autofluorescence Diagnosis Technology

作　　者：刘刚[1] 颜国正[1] 

机构地区：[1]上海交通大学医学精密工程及智能系统研究所,上海200240

出　　处：《生物医学工程学杂志》2015年第6期1348-1353,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(31170968);上海市科委资助项目(09DZ1907400)

摘　　要：自体荧光检测技术是目前新兴的癌症诊断技术,它与传统白光内窥镜相比,在癌前病变和早期癌症的诊断上有很大的优势。本文总结了国内外关于自体荧光检测技术的研究现状和进展,重点阐述了生物组织的内源性荧光分子、正常和异常生物组织荧光信号差异的来源、荧光激发光光源和波长的选择,以及荧光图像和光谱信号的处理方法。最后,本文分析并讨论了自体荧光成像与光谱技术在癌前病变和早期癌症诊断中的不足和发展方向。Autofluorescence has great advantage on detecting premalignant lesions and early cancers which are not de- tectable by conventional white light endoscopy （WLE）. In this review, the recent advances in autofluorescence for diagnosis of precancerous lesions and early cancers are presented. Varieties of endogenous fluorophores in biological tissues, the potential mechanisms of the autofluorescence differences between normal and abnormal tissues, the se- lection of light source and optimal excitation wavelengths, and effective algorithms for processing autofluorescence data are highlighted. Finally, the shortages and improvement directions of autofluorescence technique for the diagno- sis of precancerous lesions and early cancers are briefly discussed.

关 键 词：自体荧光 癌前病变 内源性荧光基团 荧光光谱与成像技术 

分 类 号：R730.43[医药卫生—肿瘤]