钙磷涂层中掺入锌对成骨的影响及其潜在生物学机制  

Effect of Zinc Doped Calcium Phosphate Coating on Bone Formation and the Underlying Biological Mechanism

作　　者：罗雯静[1] 赵静辉[1] 孟星[1] 马珊珊[1] 孙千月 郭天奇[1] 王玉峰[2] 周延民[1] 

机构地区：[1]吉林大学口腔医院种植中心,长春130021 [2]吉林大学口腔医院修复科,长春130021

出　　处：《生物医学工程学杂志》2015年第6期1359-1363,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(81200809);博士点基金资助项目(20120061110077)

摘　　要：种植体表面涂层改性可提高其骨诱导性,其中单纯钙磷涂层已被广泛研究,但其促骨整合速率慢、抗菌性低,其他金属离子如纳米锌离子的加入可弥补这些缺陷。本文阐述了该改良涂层中纳米锌的掺入形式、对材料理化性能的影响以及抑菌性,同时归纳了钙离子、锌离子和无机磷赋予材料的生物学性能主要集中于三种无机离子对成骨细胞增殖分化、蛋白合成及基质矿化等方面的作用,以全面阐述纳米掺锌钙磷涂层对骨形成的促进作用。Implant surface modified coating can improve its osteoinductivity, about which simple calcium phosphate coating has been extensively studied. But it has slow osteointegration speed and poor antibacterial property, while other metal ions added, such as nano zinc ion, can compensate for these deficiencies. This paper describes the incor- poration form, the effect on physical and chemical properties of the material and the antibacterial property of nano zinc, and summarizes the materiaVs biological property given by calcium ion, zinc ion and inorganic phosphate （Pi）, mainly focusing on the influence of these three inorganic ions on osteoblast proliferation, differentiation, protein syn- thesis and matrix mineralization in order to present the positive function of zinc doped calcium phosphate in the field of bone formation.

关 键 词：钙离子 无机磷 锌离子 成骨 骨诱导性 

分 类 号：R783.1[医药卫生—口腔医学]