IL-6基因-634G／C多态性与肺癌相关性的Meta分析  

Association between-634G/C Polymorphism in the IL-6 Gene and the Risk of Lung Cancer: A Meta-analysis

作　　者：李光清[1] 吴昭萍[1] 李小波[1] 亓占中[1] 李硕[2] 梁颖隽[1] 吴明亚[1] 张琼[1] 袁娇[1] 夏志强[3] 李东[1] 陈秋伶[1] 王馨平[1] 白洪光 

机构地区：[1]解放军第452医院呼吸内科,成都610021 [2]解放军第452医院营养科,成都610021 [3]解放军第452医院医务处,成都610021

出　　处：《中国循证医学杂志》2015年第12期1372-1377,共6页Chinese Journal of Evidence-based Medicine

基　　金：四川省科技厅科技支撑计划(编号:2011SZ0140)

摘　　要：目的系统评价IL-6基因-634G/C多态性与肺癌的相关性。方法计算机检索Pub Med、EMbase、CNKI、Wan Fang Data数据库,纳入IL-6基因-634G/C多态性与肺癌相关性的病例-对照研究,检索时限均为建库截至2015年10月。由2位研究者独立筛选文献、提取资料和评价纳入研究的方法学质量后,采用Rev Man 5.3软件进行Meta分析。结果共纳入来自11篇文献的12个病例-对照研究,包括3 657例肺癌患者和4 100例对照人群。Meta分析结果显示,IL-6基因-634G/C多态性与肺癌的发病风险不具有相关性[GG+GC vs.CC:OR=1.11,95%CI(0.89,1.39),P=0.37;GG vs.CC+GC:OR=1.17,95%CI(0.88,1.55),P=0.27;GG vs.CC:OR=1.27,95%CI(0.93,1.72),P=0.13;GC vs.CC:OR=1.12,95%CI(0.89,1.40),P=0.33;G vs.C:OR=1.08,95%CI(0.89,1.30),P=0.43]。结论 IL-6基因-634G/C多态性可能与肺癌的发病风险无关。受纳入研究的数量和质量的限制,上述结论尚需开展更多高质量研究予以证实。Objective To systematically review the association between the IL-6 gene -634G/C polymorphism and the risk of lung cancer. Methods Databases including the PubMed, EMbase, CNKI and WanFang Data were searched from inception to October 2015 to collect case-control studies about the correlation between the IL-6 gene -634G/C polymorphism and the risk of lung cancer. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software. Results A total of 12 case-control studies concerning 3 657 lung cancer cases and 4 100 controls from 11 articles were included. The results of meta-analysis showed that there was no significant association between the -634G/C polymorphism and the risk of lung cancer （GG＋GC vs. CC： OR=l.11, 95%CI 0.89 to 1.39, P=0.37; GG vs. CC＋GC： OR=1.17, 95%CI 0.88 to 1.55, P=0.27; GG vs. CC： OR=1.27, 95%CI 0.93 to 1.72, P=0.13; GC vs. CC： OR=1.12, 95%CI 0.89 to 1.40, P=0.33; G vs. C： OR=1.08, 95%CI 0.89 to 1.30, P=0.43）. Conclusion IL-6 gene -634G/C polymorphism may not be a risk factor of lung cancer. Due to the limited quality and quantity of included studies, more high quality studies are needed to verify the above conclusion.

关 键 词：肺癌 多态性 IL-6 META分析 病例一对照研究 

分 类 号：R734.2[医药卫生—肿瘤]