A retrospective Evaluation of Antibacterials Used in theManagement of Diabetics in a Tertiary Hospital inSouth-western Nigeria  

作　　者：Mopelola Ibidunni Ayeni Ezekiel Olugbenga Akinkunmi, RosemaryTemitope Ikem Patrick Osemene Adunni Morohunfola 

机构地区：[1]Department of Clinical Pharmacy and Pharmacy Administration. Obafemi Awolowo University, Ile-lfe, Osun State.22005.Nigeria [2]Department of Pharmaceuties, Obafemi Awolowo University, Ile-lfe, Osun State 22005.Nigeria [3]Department of Medicine, Obafemi Awolowo University, lle-lfe, Osun State 22005.Nigeria [4]Tots & Tykes Pediatrics, 3750 S University Dr Ste 200 Fort Worth, TX 76006. USA

出　　处：《Journal of Pharmacy and Pharmacology》2015年第3期146-151,共6页药剂与药理学（英文版）

摘　　要：Objective： Co-medication with antibacterials is often necessary in the management of diabetic patients. There is a constantneed to evaluate the use of these antibacterials to improve therapeutic outcomes and to avoid practices that could possibly increase theemergence of antimicrobial resistance. The aim of this study was to evaluate the utilization of antibacterials in the diabetic clinic of aNigerian tertiary hospital. Methods： A retrospective evaluation and analysis of patients＇ case notes written by physicians in the diabeticclinic over a three-year period （January, 2008-December, 2010） was conducted. The case notes were the individual medical records for150 different hospitalized diabetic patients with infection as co-indication. Data was collected using a WHO instrument for studies ofrational drug use. Results： Descriptive statistics such as mean, frequency, percentages and standard deviation were used to analyzecategorical data obtained from the demographic variables. Fisher exact test and chi square test were employed to determine whetherthere were statistically significant differences or associations between mean values of antibacterial prescription pattern and attendantdosage errors. （P =/〈 0.05 was accepted as significant）. Comparing the mean number of antibacterial drugs in each prescription yearlyyielded a mean of 1.32 in 2008, 1.37 in 2009 and 1.67 in 2010, indicating that there was no statistically significant difference.Antibacterials were used to manage complications often seen in the diabetic patient, including; diabetic foot gangrene, injection abscess,septiceamia, diabetic foot ulcer, vaginal yeast infection, amongst others. Conclusions： The majority of prescriptions met the criteria forcompliance with the hospital＇s drug use protocol. The few instances of non-compliance with the hospital＇s antibiotic drug use protocolmay indicate the need for continuing education, especially for the less experienced prescribers.

关 键 词：Antibiotics  diabetes  infection  WHO  Nigeria. 

分 类 号：R[医药卫生]