食管鳞癌组织中Survivin、Caspase-3和Caspase-8的表达及其临床意义  

Expressions of Survivin,Caspase-3 and Caspase-8 in the Esophageal Squamous-celled Carcinoma

作　　者：曹婧[1] 任美[1] 

机构地区：[1]郑州铁路职业技术学院,河南郑州450052

出　　处：《肿瘤基础与临床》2015年第6期477-480,共4页journal of basic and clinical oncology

摘　　要：目的探讨食管鳞癌组织中survivin、caspase-3和caspase-8的表达及临床意义,并探讨三者的相互关系。方法采用免疫组化S-P法检测105例食管鳞癌和50例癌旁正常食管黏膜组织中survivin、caspase-3和caspase-8。结果食管鳞癌组织中survivin、caspase-3和caspase-8的阳性率分别为74.3%(78/105)、37.1%(39/105)、39.0%(41/105),癌旁正常食管黏膜组织中分别为4.0%(2/50)、84.0%(42/50)、80.0%(40/50),2组比较差异均有统计学意义(P均<0.05)。食管鳞癌组织中survivin的表达与分化程度、临床分期、淋巴结转移有关(P均<0.05);食管鳞癌组织中caspase-3和caspase-8的表达均与临床分期、淋巴结转移有关(P均<0.05)。食管鳞癌组织中survivin与caspase-3和caspase-8均呈负相关关系(r=-630、-556,P均<0.05),而caspase-3和caspase-8呈正相关关系(r=0.718,P<0.05)。结论 Survivin、caspase-3和caspase-8在食管鳞癌组织中均存在异常表达,survivin可能通过抑制caspase-3、caspase-8表达而促进肿瘤的进展,三者联合检测可用于食管鳞癌的病情和预后评估。Objective To investigate the expressions of survivin, caspase-3 and caspase-8 in the esophageal squamous-celled carcinoma and the clinical significance, and to analyze their correlations. Methods Immunohistochemical S-P method was used to detect the expressions of survivin, caspase-3 and caspase-8 in the 105 cases of esophageal squamous-celled carcinoma and 50 cases of paraneoplastic normal tissues. Results The positive rates of surviving, caspase-3 and caspase-8 were 74.3% （78/105） , 37.1% （39/105） and 39.0% （41/105）in the esopha- geal squamous-celled carcinoma, and were （2/50）% , 84.0% （42/50） and 80.0% （40/50） in the paraneoplastic normal tissues （ P 〈 0. 05 ）. The expression of survivin in the esophageal squamons-celled carcinoma was related with cell differentiation, clinical stage and lymph node metastasis （ P 〈 0.05 ）. The expressions of caspase-3 and caspase-8 in the esophageal squamous-celled carcinoma were related with clinical stage and lymph node metastasis （P 〈 0.05 ）. The expression of survivin was negatively related with caspase-3 in the esophageal squamous-celled carcinoma （r = -630 ,P 〈 0.05 ）. The expression of survivin was negatively related with caspase-8 in the esophageal squamous-celled carcinoma （ r = - 556, P 〈 0. 05 ）. The expression of caspase-3 was positively related with caspase-8 in the esophageal squamous-eelled carcinoma （r = 0. 718, P 〈 0.05）. Conclusion Abnormal expressions of Survivin,caspase-3 and caspase-8 are observed in the esophageal squamons-celled carcinoma, and the associated detection can be used to evaluate the pathogenetic condition and prognosis of esophageal squamous-celled carcinoma.

关 键 词：食管鳞癌 SURVIVIN CASPASE-3 CASPASE-8 

分 类 号：R735.1[医药卫生—肿瘤] R730.23[医药卫生—临床医学]