直肠癌术后局部复发调强放疗同期卡培他滨化疗的疗效  

Intensity-modulated Radiotherapy Combined with Xeloda in the Treatment of Patients with Postoperative Recurrent Rectal Cancer

作　　者：陈亚楠[1] 左云[1] 沈冬[1] 张永芹[1] 

机构地区：[1]张家港市第一人民医院肿瘤科,江苏张家港215600

出　　处：《肿瘤基础与临床》2015年第6期491-493,共3页journal of basic and clinical oncology

摘　　要：目的观察调强放疗同期卡培他滨化疗治疗直肠癌术后局部复发的疗效及毒副反应。方法 36例直肠癌术后局部复发患者接受调强放疗同期卡培他滨化疗,观察临床疗效及毒副反应。结果 36例直肠癌术后局部复发患者均可评价疗效及毒副反应,有效率为83.3%(30/36);疼痛缓解率为87.5%(21/24);里急后重感缓解率为86.4%(19/22),便血缓解率为82.4%(14/17);1、2 a生存率分别为86.1%和61.1%。主要毒副反应为Ⅰ、Ⅱ度血液学毒性和胃肠道反应,均可耐受。结论调强放疗同期卡培他滨化疗治疗直肠癌术后局部复发安全有效。Objective To investigate the efficacy and toxicities of intensity-modulated radiotherapy combined with xeloda in the treatment of patients with postoperative recurrent rectal cancer. Methods Thirty-six patients with postoperative recurrent rectal cancer received intensity-modulated radiotherapy combined with xeloda chemotherapy. The clinical efficacy and toxicities were observed. Results Of the 36 patients,the rate was 83.3% （30/36） ,the pain remission rate was 87.5% （21/24）, the tenesmus remission rate was 86.4% （ 19/22 ）, the bematochezia remis- sion rate was 82.4% （14/17） ; The 1-year and 2-year survival rate were 86.1% and 61.1% respectively. The main toxicities were I or II degree hematological toxicities and gastrointestinal reaction, and could be tolerable. Conclusion Intensity-modulated radiotherapy combined with xeloda is an effective and safe method for patients with post- operative recurrent rectal cancer.

关 键 词：直肠癌 调强放疗 卡培他滨 

分 类 号：R735.37[医药卫生—肿瘤] R730.58[医药卫生—临床医学]