平阳霉素与肝素钠皮内注射治疗睑黄瘤临床疗效比较  

Comparison of Clinical Efficacy of Intradermal Injection of Peplomycin and Heparin Sodium in the Treatment of Eyelid Xanthoma

作　　者：孔晓路[1] 

机构地区：[1]郑州市第二人民医院眼科,河南郑州450000

出　　处：《肿瘤基础与临床》2015年第6期501-502,共2页journal of basic and clinical oncology

摘　　要：目的比较分析平阳霉素与肝素钠皮内注射治疗睑黄瘤的疗效。方法 101例病理学确诊的睑黄瘤患者随机分为治疗组和对照组,其中治疗组53例患者105眼行皮内注射盐酸平阳霉素,对照组48例96眼行皮内注射肝素钠,比较2组的疗效。结果治疗组99眼(94.3%)治愈,6眼(5.7%)好转,其中治愈者中有3眼(3.0%)复发;对照组91眼(94.8%)治愈,5眼(5.2%)好转,其中治愈者中有2眼(2.2%)复发,2组的治愈率、好转率、复发率比较差异均无统计学意义(P>0.05)。与对照组比较,治疗组的治疗次数少,治愈时间短(P<0.05)。结论皮内注射平阳霉素与肝素钠治疗睑黄瘤均安全有效,具有高治愈率和低复发率,但皮内注射盐酸平阳霉素在治疗时间和次数方面更具优势。Objective To compare the clinical efficacy of intradermal injection of peplomycin and heparin sodium in the treatment of eyelid xanthoma. Methods The 101 patients with eyelid xanthoma were randomly divided into two groups, 53 patients （105 eyes）of the treatment group were treated with intradermal injection of peplomycin and heparin sodium, and 48 patients （96 eyes）of the control group were treated with intradermal injection of heparin sodium. The clinical efficacy was compared between the two groups. Results In the treatment group, 99 eyes （94.3%） were cured, 6 eyes （5.7%）were improved, and 3 eyes （3.0%）were relapsed. In the control group, 91 eyes （94.8%）were cured, 5 eyes （5.2%）were improved and 2 eyes （2.2%）were relapsed. There was no statisti- cal difference in the cure rate, improvement rate and relapse rate between the two groups. The treatment number of times and treatment time of the treatment group were higher than those of the control group. Conclusion Peplomycin and heparin therapy safe and effective for eyelid xanthoma, have a low recurrence rate. However, peplomycin has an advantage in the treatment number of times and treatment time.

关 键 词：盐酸平阳霉素 肝素钠 睑黄瘤 皮内注射 

分 类 号：R739.71[医药卫生—肿瘤]