Fibrinolytic Activity of Some Nigerian Medicinal Plants  

作　　者：Omotoso Abayomi Ebenezer Ezealisiji Kenneth Bagbi Baribefe Monday Maduakor Ogochukwu Hilda 

机构地区：[1]Department of Medicinal and Pharmaceutical Chemistry, University of Port-Harcourt, Port-Harcourt 500001, Nigeria [2]Department of Clinical Pharmacy and Experimental Pharmacology, University of Port-Harcourt, Port-Harcourt 500001, Nigeria

出　　处：《Journal of Pharmacy and Pharmacology》2014年第3期177-184,共8页药剂与药理学（英文版）

摘　　要：The first line drugs in the management of thromboernbolic diseases in Nigeria include Urokinase and Streptokinase. These drugs come with their attendant shortcomings. The need to source for cheap and accessible alternative therapy forms the basis of this study. The fibrinolytic potentials of 10 Nigerian medicinal plants： Anona senegalensis, Buchholzia coriaceae, Citrullus colocynthis, Cnidoscolus aconitifolius, Curculigo pilosa, Nicotiana tabaccum, Parinari curatellifolia, Pepperomia pellucida, Sida acuta and Xylopia aethiopica extracts were evaluated using water and streptokinase as negative and positive controls respectively. Trace metal （Cu, Fe, Ca and Zn） analysis of the plant extracts was carried out using atomic absorption spectrophotometer. Methodology involved in vitro clot lysis method, the crude methanolic extract ofParinari curatellifolia （56.122%）, Cnidoscolus aconitifolius （48.385%）, Anona senegalensis （46.360%）, Xylopia aethiopica （43.205%） and Buchholzia coriaceae （27.062%） were found to have significant （P 〉 0.001） fibrinolytic activity. Maximum effect was exhibited by the positive standard： Streptokinase （60.20 ± 4.30%）, followed by Parinari curatellifolia （56.122 ± 3.86%）, our findings reveal that fibrinolytic activity is independent of elemental Copper or Iron content of the extracts. This study indicated that methanolic extracts of Parinari curatellifolia, Cnidoscolus aconitifolius, Anona senegalensis, Xylopia aethiopica and Buchholzia coriaceae could serve as cheap and accessible alternative.

关 键 词：FIBRINOLYTIC Anona senegalensis Xylopia aethiopica CALCIUM streptokinase. 

分 类 号：R9[医药卫生—药学]