难治性精神分裂症患者脑局部一致性的功能磁共振研究  

A study of resting-state functional magnetic resonance imaging in treatment-refractory schizophrenia patients using regional homogeneity

作　　者：徐西嘉[1] 史晓蒙 彭子文[2] 王筱兰[1] 孙静[1] 姚辉[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,210029 [2]华南师范大学心理学院

出　　处：《临床精神医学杂志》2015年第6期377-380,共4页Journal of Clinical Psychiatry

基　　金：南京市医学科技发展资金资助项目(QRX11121;ZKX08034);江苏省卫生厅面上项目(H200875);江苏省医学重点学科(精神病学;江苏省卫生厅2011-12);国家临床重点专科建设项目(精神科;卫生部医政司2011-873)

摘　　要：目的:探讨难治性精神分裂症患者在静息状态下的脑功能活动情况。方法:采用局部一致性(Re Ho)方法,对24例难治性精神分裂症患者(患者组)和21名与之相匹配的正常人(正常对照组)在静息状态下脑功能活动情况进行比较分析。结果:与正常对照组相比,患者组在静息状态下Re Ho增强的脑区为双侧楔前叶、右内侧前额叶和右侧颞上回;Re Ho降低的脑区为左侧脑干(未校正,P<0.001,cluster>10)。结论:难治性精神分裂症患者在静息状态下发生功能活动改变的脑区主要集中于默认网络内。Objective：To investigate brain activities in treatment-refractory schizophrenia patients during the resting-state situation.Method：Twenty-four treatment-refractory schizophrenia patients and 21 healthy control subjects were imaged with functional magnetic resonance imaging and analyzed with the regional homogeneity（ Re Ho） method.Results：Compared with healthy controls,increased Re Ho was found in bilateral precuneus,right medial prefrontal cortex and right superior temporal lobe in treatment-refractory schizophrenia patients,while decreased Re Ho was found in left brainstem（ P〈0.001,clusters 〉10,uncorrected）.Conclusion：Our findings indicated abnormal brain activities distributed in treatment-refractory schizophrenia patients were mainly existed in the default mode networks.

关 键 词：难治性精神分裂症 静息态功能磁共振 局部一致性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]