促衰变因子在三阴性乳腺癌中的表达及其对预后的影响  

Research on protein expression of CD55 in triple-negative breast cancer and its effect on prognosis

作　　者：李铁军[1] 张海燕[2] 姜伟[1] 

机构地区：[1]沧州市中心医院教学处,河北沧州061001 [2]沧州医学高等专科学校,河北沧州061001

出　　处：《中国医学装备》2015年第12期41-44,共4页China Medical Equipment

基　　金：沧州市科学技术研究项目(131302105)"凋亡抑制因子Livin与抑癌基因PTEN在三阴性乳腺癌中的表达及其判断乳腺癌预后价值的研究"

摘　　要：目的:探讨长度促衰变因子(DAF,CD55)在三阴性乳腺癌(TNBC)中的表达及与预后的关系。方法:用免疫组化S-P法检测100例TNBC及50例TNBC旁乳腺组织中CD55的表达;结合临床病理和随访资料,建立Cox模型进行预后分析。结果:CD55在TNBC中的表达率为56.0%,在癌旁乳腺中的表达率为8.0%,两者之间差异有统计学意义(x2=32.0,P<0.05)。CD55的表达与肿瘤大小、临床分期及腋下淋巴结转移均具有显著相关(x2=7.404,x2=8.688,x2=4.802;P<0.05),而与年龄和组织学分级无显著相关。多因素分析显示,年龄、临床分期、CD55及腋淋巴结转移情况4项指标是影响患者DFS的独立危险因素;临床分期及腋淋巴结转移情况两项指标是影响患者OS的独立危险因素。结论:CD55的高表达可能参与了TNBC的发生、发展过程,并与预后有相关性,提示CD55的表达可能成为判断TNBC浸润进展及预后的指标之一。Objective： To investigate the expression of CD55 in triple-negative breast cancer（TNBC） and its correlations with prognosis. Methods： The expressions of CD55 was detected by immunohistochemistry Streptavidin-Peroxidase method in 100 cases of triple-negative breast cancer and 50 cases of adjacent-carcinoma tissues, with clinical and pathological features and follow-up data, the Cox model analysis was established and to analyze the prognostic factors. Results： The positive expression of CD55 was 56.0% in the tissues from triple-negative breast cancer, whereas its positive rate was 8.0% in the corresponding adjacent breast tissues, with statistical significance（x^2=32.0, P〈0.05）. The expression of CD55 was significantly related with tumor size, clinical stage and axillary lymph node metastases（x^2=7.404, x^2=8.688, x^2=4.802; P〈0.05）; the expression of CD55 did not show correlation to age, and histologic grade. Multivariate analysis showed that the age, clinical stage, CD55 protein expression and axillary lymph node metastasis were the independent risk factors affecting the 5-year disease-free rate of patients and that clinical stage and axillary lymph node metastasis were the independent risk factors affecting the 5-year overall rate of patients. Conclusion： The expression of CD55 might be related to the development and prognosis of triple-negative breast cancer. The expression of CD55 may be used as one of the indicators in determining the progress and prognosis of TNBC.

关 键 词：三阴性乳腺癌 促衰变因子 免疫组织化学 预后 

分 类 号：R737.9[医药卫生—肿瘤]