血清唾液酸、上皮膜抗原和甘氨酰脯氨酸二肽氨基肽酶检测在胃癌诊断中的价值研究  

Research on the diagnostic performance of measurements of serum SA, EMA and GPDA in gastric cancer diagnosis

作　　者：项文坤[1] 熊锋宝[1] 杨铁一[1] 付唆林[1] 

机构地区：[1]南昌大学第三附属医院消化内科,江西南昌330008

出　　处：《中国医学装备》2015年第12期93-95,共3页China Medical Equipment

基　　金：江西省卫生厅资助项目(20080262)"联合检测CYFRA21-1;EMA;GPDA对胃癌诊断的临床研究"

摘　　要：目的:探讨检测血清唾液酸(SA),上皮膜抗原(EMA)和甘氨酰脯氨酸二肽氨基肽酶(GPDA)在胃癌诊断中的敏感性、特异性、准确度以及阳性似然比。方法:选取经电子胃镜及病理检查确诊的30例胃癌患者、25例胃癌前病变患者及35例非萎缩性胃炎患者,对其血清SA、EMA及GPDA分别进行测定,计算血清SA、EMA和GPDA单项及联合检测胃癌的敏感性,特异性,诊断准确度和阳性似然比,并比较其差异。结果:单项检测中以SA最敏感、GPDA的特异度和诊断准确率最高,其灵敏度、特异度和准确率分别为50.00%、97.14%和90.99%。且诊断价值最大(LR+=11.65)。联合检测SA,GPDA可以提高诊断灵敏度53.33%。血清EMA对胃癌诊断无差异。结论:检测血清SA和GPDA对于胃癌的诊断有重要参考价值,SA和GPDA的联合检测可提高胃癌诊断的准确性,检测血清EMA对胃癌诊断可能无价值。Objective： To study the diagnostic performance of measurements of serum SA, EMA and GPDA in gastric cancer patients. Methods： We detect serum SA, EMA and GPDA in 30 cases of patients with gastric cancer patients, 25 cases of patients with gastric precancerous lesions and 35 cases of patients with non-atrophic gastritis with electronic gastroscope and pathological examination confirmed, the sensitivity, specificity, diagnosis accuracy and positive likelihood ratio were calculated about alone and combinative measurements of the markers in the diagnosis of gastric cancer. Results： A single detection of SA in the most sensitive（50.00%）, GPDA the highest specificity（97.14%）, one of the diagnostic accuracy GPDA the highest（90.99%）, and the greatest diagnostic value（LR＋=11.65）. Joint detection SA, GPDA can improve the diagnostic sensitivity（53.33%）, serum EMA is not a valuable marker in the diagnostic of gastric cancer. Conclusion： It has an important reference value for the diagnosis of gastric cancer to detect serum SA and GPDA. The joint detection SA and GPDA can improve the accuracy of the diagnosis of gastric cancer. EMA serum possibly has no diagnostic value for gastric cancer.

关 键 词：胃癌 胃癌前病变 非萎缩性胃炎 唾液酸 上皮膜抗原 甘氨酰脯氨酸二肽氨基肽酶 

分 类 号：R735.2[医药卫生—肿瘤]