MitoQ对神经系统保护作用的研究进展  

Research Progress in Neuroprotection of MitoQ

作　　者：郑铎[1] 高柏[1] 佡剑非[1] 

机构地区：[1]中国医科大学附属盛京医院神经内科,沈阳110004

出　　处：《医学综述》2015年第24期4457-4460,共4页Medical Recapitulate

摘　　要：线粒体靶向抗氧化剂MitoQ是泛癸利酮的一种合成类似物,能靶向聚集于线粒体中清除过度生成的氧自由基,也能抑制脂质过氧化反应,保护线粒体膜免受氧化应激损伤,从而改善线粒体功能。MitoQ在以线粒体功能障碍和氧化应激损伤为主要病理表现的神经系统疾病(如脑缺血、阿尔茨海默病、帕金森病、弗里德赖希共济失调、多发性硬化)中均具有一定的作用。MitoQ is a synthetic analogue of coenzyme Q10. As a mitochondrial targeted antioxidant,MitoQ could directionally accumulate in mitochondrial to remove excessive oxygen free radicals. Simultaneously,it also can inhibit lipid peroxidation,protect mitochondria and cell membranes from oxidative stress damage,and improve the mitochondrial function. Rencently,many studies have shown that MitoQ has certain effects in treating nervous system diseases with mitochondrial dysfunction and oxidative stress damage as main pathological manifestations,such as cerebral ischemia,Alzheimer disease,Parkinson disease,Friedreich ataxia,and multiple sclerosis.

关 键 词：MITOQ 泛癸利酮 线粒体靶向抗氧化剂 神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]