粪便生物标志物在炎症性肠病中的应用  

Fecal biomarkers in diagnosis and management of inflammatory bowel disease

作　　者：叶院宁 汪芳裕[1] 

机构地区：[1]南方医科大学金陵医院(南京军区南京总医院)消化内科,江苏南京210002

出　　处：《胃肠病学和肝病学杂志》2015年第12期1517-1521,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(81270453)

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是一种病因不明的慢性非特异性肠道炎症性疾病,主要包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn’s disease,CD)。IBD的诊断和监测主要依靠临床症状、内镜表现、组织病理学及影像学等。近年来,大量研究证实粪便生物标志物,如钙卫蛋白(fecal calprotectin,FC)和乳铁蛋白(lactoferrin,LF)是肠道炎症直接产物,可以作为IBD诊断及病情监测的一种准确的、非侵入性指标,而且可能成为内镜下诊断炎症活动性的替代指标。本文旨在阐述粪便标志物在IBD的诊断、监测、评价预后等方面的临床运用。Inflammatory bowel disease （IBD） is an unclear etiologic and chronic non-specific intestinal inflammatory disease, primary including ulcerative colitis （UC） and Crohn＇ s disease （CD）. Diagnosis and management of IBD mainly rely on clinical, endoscopic, and radiologic parameters. Recently,fecal inflammatory biomarkers such as ealpro- tectin and lactoferrin which are direct products of bowel inflammation, and they can provide an accurate and noninvasive diagnostic and monitoring modality for CD and UC, and may become a surrogate marker for endoscopic diagnosis of in- flammatory activity. This article contains an overview of the currently existing literature pertaining to clinical implications of fecal biomarkers for diagnosis, monitoring, and prediction of outcomes of IBD.

关 键 词：克罗恩病 溃疡性结肠炎 粪便生物标志物 粪便钙卫蛋白 粪便乳铁蛋白 

分 类 号：R574[医药卫生—消化系统]