食管原发性神经内分泌癌33例临床病理分析  

Esophageal primary neuroendocrine carcinoma:a clinicopathologic and immunohistochemical study of 33 cases

作　　者：隋燕霞[1] 张勇[2] 党诚学[3] 宋永春[3] 张晓智[4] 任娟[4] 高莹[4] 赵东利[4] 

机构地区：[1]西安交通大学第一附属医院病理科,西安710061 [2]西安交通大学第一附属医院胸外科,西安710061 [3]西安交通大学第一附属医院肿瘤外科,西安710061 [4]西安交通大学第一附属医院肿瘤放疗科,西安710061

出　　处：《诊断病理学杂志》2015年第12期740-743,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨食管原发性神经内分泌癌（NEC）的临床病理特点。方法对33例根治性手术切除的食管原发性NEC进行临床病理学观察,并行免疫组化检测。结果 33例食管原发性NEC占同期食管癌根治性手术病例的4%（33/829）。其中男性23例,女性10例,男女之比为2.3∶1。发病年龄45~82岁,平均年龄61.3岁。病理检查示食管原发性NEC分为小细胞神经内分泌癌和大细胞神经内分泌癌,两者可单独存在也可混合存在。免疫组化染色主要表达神经内分泌标记物。33例标本中仅7例肿瘤组织由单一的神经内分泌癌组织构成,其余26例均为混合型,主要混有不同分化程度的鳞状细胞癌,其中2例混有基底细胞样鳞状细胞癌,1例混有少量腺癌。结论食管原发性NEC是一种较为少见的食管恶性肿瘤,确诊主要依据病理组织学特点及免疫组化检查。Objective To study the clinicpathological characteristics of primary neuroendocrine carcinoma of the esophagus.Methods Clinicpathological characteristics were observed in 33 cases of resected esophageal primary neuroendocrine carcinoma,immunohistochemical staining was carried out.Results 33 cases of primary neuroendocrine carcinoma of the esophagus were taken（ 3.98%,33 /829） in all resection of esophageal carcinoma in the same period.Among the 33 cases,23 cases were male patients,the rest were women patients.The age of the patients were ranged from45 to 82 years,and the mean age of the patients was 61.33 ± 9.78 years.Pathological examination showed neuroendocrine carcinoma that can be divided into small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma,both can exist alone or mixed.Immunohistochemical staining expressed neuroendoerine markers.In 33 cases of radical resection specimen only 7 cases of tumor tissue consisted of a single neuroendocrine carcinoma,the rest of the 26 cases were mixed,mainly mixed with different differentiation of squamous cell carcinoma,2 cases with basoloid-squamous cell carcinoma,1case with a small amount of differentiation adenocarcinoma.Conclusion Esophageal primary neuroendocrine carcinoma is a relatively rare esophageal malignant tumor,and its diagnosis based primarily on histologic features and immunohistochemical examination.So the pathologic features combined with immunohistochemical characteristics are the basis of an accurate diagnosis.

关 键 词：食管 神经内分泌癌 病理 免疫组化 

分 类 号：R735.1[医药卫生—肿瘤]