颗粒细胞瘤11例临床病理分析  

Granular cell tumor:a clinicopathologic analysis of 11 cases

作　　者：王全义[1] 冯彦丽[2] 赵丽华[1] 张仁亚[1] 

机构地区：[1]济宁医学院附属医院病理科,山东济宁272029 [2]济宁医学院附属医院妇科,山东济宁272029

出　　处：《诊断病理学杂志》2015年第12期753-756,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨颗粒细胞瘤（GCT）的临床病理特征、鉴别诊断及预后。方法复习11例GCT的临床资料,进行组织细胞形态和免疫组化观察。结果 11例颗粒细胞瘤均为良性,男性5例,女性6例;年龄24~61岁,平均46.2岁。肿瘤直径0.8~6 cm,平均直径2.3 cm,均为单发病例。临床主要表现为真皮、皮下或黏膜下孤立无痛性结节。组织学特点为无明显被膜,瘤细胞体积较大,呈圆形,胞质丰富,可见较多嗜伊红均质细颗粒。免疫组化示肿瘤细胞NSE、S-100及CD68均为强（＋）,vimentin部分（＋）,9例不同程度TFE3（＋）;CK、CD34、SMA、GFAP和NF均为（-）。随访3个月~5年,均无复发和远处转移。结论 GCT为一种少见的良性软组织肿瘤,典型的组织学表现结合免疫组化可以明确诊断。TFE3是诊断GCT有价值的免疫组化标记物。手术切除为首选治疗方法,总体预后良好。Objective To investigate the clinical pathological characteristics,diagnosis,differential diagnosis and prognosis of granular cell tumor.Methods 11 cases of granular cell tumor were studied by histopathological observation and immunohistochemical staining.Results Our study included 11 cases of benign granular cell tumor.There were 5male and 6 female patients.Ages ranged from 24 to 61 years（ mean 46.2 years）.The tumor size ranged from 0.8 to 6 cm（ mean 2.3 cm）.They were all for single.All cases were mainly manifested as a solitary painless nodule located in the derma,subcutaneous and submucosal tissues.The histological features of the tumor were that there was no complete capsule around tumor and tumor cells were round and relatively larger,in which a lot of eosinophilic granules.Immunohistochemical study showed strongly positive staining for NSE,S-100 and CD 68 in all cases,in part of cases were positive for vimentin,9 out of 11 cases were different positive for TFE3.All the cases were negative for CK,CD34,SMA,GFAP and NF.These patients were followed up for 3 months to 5 years,and they had no recurrence and metastasis.Conclusions GCT is a rare benign soft tissue tumor.Typical histological findings with the results of immunohistochemistry can usually be diagnosed.TFE3 antibody is a particularly valuable marker in the pathologic diagnosis of GCT.Surgical resection is curative for these patients.They have a relatively good prognosis.

关 键 词：颗粒细胞瘤 免疫组化 转录因子E3 临床病理 

分 类 号：R738.6[医药卫生—肿瘤]