交联葡聚糖凝胶微球颗粒栓塞治疗肝癌疗效的初步观察  

Preliminary observation of embolization effect for primary liver cancer using sephadex gel microspheres

作　　者：岳琨[1] 李晓冰[1] 宫卫东[1] 吴智群[1] 

机构地区：[1]第四军医大学唐都医院介入放射科,陕西西安710038

出　　处：《实用放射学杂志》2015年第12期2019-2021,共3页Journal of Practical Radiology

摘　　要：目的 观察交联葡聚糖凝胶微球颗粒栓塞剂对肝癌的临床疗效和不良反应，对其有效性、安全性做出评价。方法 将 12例确诊为原发性肝癌的患者经导管使用交联葡聚糖凝胶微球颗粒栓塞，行TACE术后180 d内，分别通过对患者栓塞术后不良反应、生存率和影像学表现评估其疗效。结果 栓塞后45 d复查，4例患者的肿瘤区域内出现液性坏死区；6例患者的肿瘤面积明显缩小。栓塞后90 d，患者原病灶坏死明显，均无再次栓塞治疗需要；栓塞后180 d，患者生存率100%。结论 使用交联葡聚糖凝胶微球颗粒栓塞剂治疗原发性肝癌具有疗效肯定、安全有效的特点，有较好的临床治疗价值。Objective To explore the efficacy and security of sephadex gel microspheres in embolization treatment of primary liver cancer. Methods 12 patients with primary liver cancer confirmed by the clinical and pathological examination were embolized with sephadex gel microspheres. Respectively by means of embolism in patients with postoperative adverse reactions,the survival rate and imaging findings to assess their curative effect,during the 180 days after treatment. Results After 45 days of the embolization, liquetided necrosis appeared in the tumor in 4 patients, and tumor size was significantly reduced in 6 patients. After 90 days of the embolization, re-embolism was not performed because of obvious necrosis of the tumor. After 180 days of the embolization, the patient survival of 100% was observed. Conclusion Embolization with sephadex gel microspheres is effective, simple, convenient and safe for treatment of primary liver cancer.

关 键 词：原发性肝癌 交联葡聚糖凝胶微球颗粒 经导管肝动脉化疗栓塞术 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]