新型含取代吡啶环的取代吡唑甲醛肟的合成及生物活性测定  

Synthesis and Biological Activities of Novel Substituted Pyrazole Oximes Containing Substituted Pyridine Group

作　　者：戴红[1] 庄辉阳 施磊[1] 李刚[1] 张海军[1] 方源[1] 戴宝江[2,3] 

机构地区：[1]南通大学化学化工学院,南通226019 [2]南通南沈植保科技开发有限公司,南通226017 [3]南通职业大学化学与生物工程学院,南通226007

出　　处：《有机化学》2015年第11期2399-2404,共6页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21202089;21372135);南通市科技计划(No.AS2013002)资助项目~~

摘　　要：为了从吡唑肟类化合物中寻找新的活性物质,利用活性亚结构拼接原理,将取代吡啶骨架引入到吡唑肟分子结构中,制备了一系列未见文献报道的新型含取代吡啶环结构的取代吡唑甲醛肟化合物.通过核磁氢谱、碳谱和元素分析确证了新化合物的结构.初步的生物活性测试结果显示,某些标题化合物表现出一定的杀虫与杀螨活性.其中化合物5i在浓度为400μg/m L时对蚕豆蚜的杀死率达到90%.In order to explore novel potent pesticide from pyrazole oxime derivatives, a series of new pyrazole oxime ester compounds bearing substituted pyridine moiety were synthesized by the introduction of pyridyl backbone into the molecules of pyrazole oxime. Their structures were confirmed by 1H NMR, 13 C NMR and elemental analysis. Preliminary bioassay results showed that some of the title compounds displayed certain insecticidal and acaricidal activities. For example, compound 5i exhibited insecticidal activity against Aphis craccivora with 90% mortality at the concentration of 400 μg/mL.

关 键 词：取代吡啶 吡唑肟 合成 生物活性 

分 类 号：O626[理学—有机化学]