主动脉瓣退行性变与脑动脉粥样硬化的相关性研究  

Correlation study on aortic valve degenerative and cerebral atherosclerosis

作　　者：马征[1] 杨文娟[2] 王丽娟[3] 尚丽婕 陈大鹏[2] 薛莉[2] 纳丽莎[1] 

机构地区：[1]宁夏医科大学总医院心脏中心功能检查部,宁夏银川750004 [2]宁夏医科大学总医院心脏中心内科,宁夏银川750004 [3]宁夏医科大学总医院神经中心电生理科,宁夏银川750004

出　　处：《宁夏医学杂志》2015年第12期1085-1087,I0001,共4页Ningxia Medical Journal

摘　　要：目的探讨主动脉瓣退行性变(AVD)与脑动脉粥样硬化(CA)之间的关系。方法 132例体检者行经胸超声心动图(TTE)和经颅多普勒(TCD)检查,记录测量指标,比较脑动脉粥样硬化组与正常组间各测量指标差异,寻找脑动脉粥样硬化的独立预测因子。结果 132例体检者中,脑动脉硬化组65例,正常对照组67例,其中主动脉瓣退行性变66例,主动脉瓣退行性变合并主动脉瓣反流(AVD+AR)66例。2组间年龄、升主动脉内径、AVD+AR指标间比较,差异有统计学意义(P<0.05),且与脑动脉粥样硬化存在正相关。Logistic回归显示,年龄、升主动脉内径增宽、AVD+AR为脑动脉粥样硬化的独立预测因子,总体预测概率ROC曲线下面积为0.818,诊断准确度达到中等,获取预测脑动脉硬化的最小分界值为升主动脉内径>30 mm、年龄≥55岁。结论年龄、升主动脉内径增宽、AVD+AR可作为体检者中预测脑动脉粥样硬化的独立预测因子,具有重要的临床参考价值。Objective To study the relationship between aortic valve degenerative （AVD） and cerebral atherosclerosis （CA）. Methods 132 people for healthy examination performed by transthoraeic echocardiography （TIE） and transcranial doppler （TCD）, re- corded the detection indexes and compared the difference results between the cerebral atherosclerosis group and the normal control group, then found the independent predictive factors for cerebral atherosclerosis. Results Among the 132 people,there were 65 people in cere- bral arteriosclerosis group and 67 people in normal control group, the total of aortic valve degeneration were 66 people, and the aortic valve degeneration combined with aortic regurgitation （ AVD plus AR） were 66 people. Compared with age, the internal diameter of the ascending aorta and the AVD plus AR had significant difference （ P 〈 0.05 ） between two groups, and also had positive correlation with the cerebral artery atherosclerosis. The Logistic regression analysis showed that age ,the diameter of the ascending aorta and AVD plus AR were independent predictive factors for cerebral atherosclerosis. The area under the ROC curve was 0. 818, and the diagnostic accuracy reach medium level. Obtained the minimum cut - off point for predicting cerebral atherosclerosis was ascending aorta diameter 〉 30mm and age ≥55 years old. Conclusion The index of the age, the diameter of the ascending aorta, and the AVD plus AR can be used as the independent predictive factor for cerebral atherosclerosis ,which have important clinical reference value.

关 键 词：超声心动图 主动脉瓣退行性变 经颅多普勒超声 脑动脉粥样硬化 

分 类 号：R743[医药卫生—神经病学与精神病学] R543.1[医药卫生—临床医学]