乙肝肝硬化与酒精性肝硬化患者血清微量元素之间差异及影响因素的研究  

Difference of trace element in patients with hepatitis B and alcoholic liver cirrhosis and related factors analysis

作　　者：张铁英[1] 康杰[1] 

机构地区：[1]宁夏银川市第一人民医院消化内科,宁夏银川750001

出　　处：《宁夏医学杂志》2015年第12期1096-1098,共3页Ningxia Medical Journal

摘　　要：目的探讨乙肝肝硬化与酒精性肝硬化患者血清中微量元素间的差异,了解其可能的影响因素,为患者临床治疗和预防提供依据。方法选取乙肝病毒肝硬化和酒精性肝硬化患者各40例,采用原子吸收光度法对各组患者血清中的铁、铜、钙、镁、锌、硒和磷含量进行检测,并采用自填式问卷对可能影响体内微量元素含量的影响因素进行调查分析。结果乙肝肝硬化与酒精性肝硬化患者血清铁、钙、镁含量之间比较,差异无统计学意义。酒精性肝硬化患者铜和磷含量明显高于乙肝肝硬化患者,差异有统计学意义(P<0.05);锌含量则明显低于乙肝肝硬化组,差异有统计学意义(P<0.05)。随着病情的加重,乙肝肝硬化组与酒精性肝硬化组患者血清铁、铜含量均有上升的趋势,钙、镁、锌和磷含量则有所降低。多元回归分析发现在乙肝肝硬化患者中,微量元素的变化与BMI、年龄、患病年限、乙肝家族史、负性情绪和低蛋白饮食等因素具有较强相关性;而在酒精性肝硬化患者中,微量元素的变化则与性别、BMI、血糖、甘油三酯、职业和经济水平相关性较强。结论乙肝肝硬化与酒精性肝硬化患者的血铜、锌和磷含量间存在差异,影响两种肝硬化患者血清微量元素的因素分布不一致,乙肝肝硬化患者多与病情相关,而酒精性肝硬化患者则多受生活习惯和社会经济水平影响。Objective To study the difference of serum trace elements between patients with hepatitis cirrhosis and alcoholic cirrhosis and to provide evidence to clinical treatment and precaution. Methods 40 hepatitis cirrhosis patients and 40 alcoholic cirrhosis patients were included in this study, the concentration of serum Fe, Cu, Ca, Mg, Zn, Se and P of all patients were detected by atomic ab- sorption spectrophotometer. And the related factors which could impact the concentration of serum trace elements were investigated by questionnaire. Results The differences of serum Fe, Ca, Mg concentrations between patients in hepatitis cirrhosis and alcoholic cirrhosis were not statistically significant. The serum concentratiQn of Cu and P in alcoholic cirrhosis group were much higher than those in patients with hepatitis cirrhosis, the differences of the two groups were statistically significant （P 〈 0.05 ）, while the concentration of Zn was much lower,the difference was statistically significant （P 〈 0.05 ）. The concentration of serum Fe, Cu in the two groups increased as the devel- opment the diseases, and the concentration of Ca, Mg,Zn and P decreased at the same time. The fluctuation of serum trace concentration had strong correlation with BMI, age, disease history, HBV family history, negative emotion and low - protein diet in hepatitis cirrhosis pa- tients, hut in alcoholic cirrhosis patients, the trace element concentration had strong correlation with gender, BMI, glucose, triglyceride, oc- cupation and economic level. Conclusion The serum concentration of Cu,Zn and P are statistically significant between patients of hepa- titis cirrhosis and alcoholic cirrhosis ,the factors which affect patients in the two groups are not consistent ,the disease related factors affect patients with hepatitis cirrhosis more, while the patients with alcoholic cirrhosis are more susceptible with habits and social economical factors.

关 键 词：酒精性肝硬化 乙肝肝硬化 微量元素 影响因素 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]