Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes  

作　　者：GHELDIU Ana-Maria POPA Daniela-Saveta LOGHIN Felicia VLASE Laurian 

机构地区：[1]Department of Pharmaceutical Technology and Biopharmacy,Faculty of Pharmacy,‘Iuliu Hatieganu’University of Medicine and Pharmacy Cluj-Napoca [2]Department of Toxicology,Faculty of Pharmacy,‘Iuliu Hatieganu’University of Medicine and Pharmacy Cluj-Napoca

出　　处：《Biomedical and Environmental Sciences》2015年第11期834-838,共5页生物医学与环境科学（英文版）

基　　金：supported by a POSDRU grant;No.159/1.5/S/136893 grant with title:‘Parteneriat strategic pentru crecterea calitarii cercetarii stiintifice din universitatile medicale prin acordarea de burse doctorale?i postdoctorale-Doc Med.Net_2.0’

摘　　要：Genistein, the main isoflavone from soy, and bisphenol A （BPA）, a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BPA on estrone （El） metabolism in rat liver microsomes. Both substances inhibited the 2-hydroxylation and 16a-hydroxylation of E1, but in different degrees, thereby reducing the 2-OH-E1/16a-OH-E1 ratio,Genistein, the main isoflavone from soy, and bisphenol A （BPA）, a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BPA on estrone （El） metabolism in rat liver microsomes. Both substances inhibited the 2-hydroxylation and 16a-hydroxylation of E1, but in different degrees, thereby reducing the 2-OH-E1/16a-OH-E1 ratio,

关 键 词：BPA Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes 

分 类 号：R575[医药卫生—消化系统]