阿立哌唑和利培酮对精神分裂症患者自发脑活动的不同影响  

Different effects of taking aripiprazole and risperidone on spontaneous brain activity in schizophrenics

作　　者：常鑫[1] 罗程[1,2] 侯昌月 陈琳[2] 陈曦[2] 贺辉[2] 段明君[1,3] 蒋宇超[1] 尧德中[1,2] 

机构地区：[1]电子科技大学生命科学与技术学院,神经信息教育部重点实验室,成都610054 [2]电子科技大学信息医学研究中心,神经信息国际联合研究中心(科技部),成都610054 [3]成都市第四人民医院精神科,610036

出　　处：《四川精神卫生》2015年第6期492-495,共4页Sichuan Mental Health

基　　金：国家自然科学基金(81471638)

摘　　要：目的探究临床常用抗精神病药物阿立哌唑和利培酮对精神分裂症患者自发性脑活动的不同影响。方法纳入就诊于成都市第四人民医院的长期服用阿立哌唑进行单药治疗的精神分裂症患者9例,服用利培酮单药治疗的精神分裂症患者10例,进行静息态功能磁共振(f MRI)扫描。分析两组患者f MRI信号的分数低频振幅(f ALFF)的组间差异。结果与阿立哌唑组比较,利培酮组f ALFF显著降低的脑区有双侧壳核、嗅皮质、尾状核、眶部额下回和右侧苍白球;f ALFF显著增高脑区有左侧颞中回和左侧缘上回(P<0.05)。结论阿立哌唑和利培酮会对大脑产生不同影响,差异脑区符合两种药物的不同药理机制。Objective To explore the difference in effects of taking two different kinds of drugs aripiprazole and risperidone on spontaneous brain activity among schizophrenics. Methods Nineteen patients(9 patients taking aripiprazole and 10 patients taking risperidone),who were recruited in the Fourth Peopleˊs Hospital of Chengdu were underwent a resting - state scanning at the Center for Information in Medicine of University of Electronic Science and Technology of China. Two groupsˊfractional amplitude of low - frequency (fALFF)value were calculated and compared using two sample t - test. Results Compared with the aripiprazole group,risperidone group showed significantly decreasing areas of fALFF,including bilateral putamen,olfactory,caudate,orbitofrontal and right palli-dum;left middle temporal gyrus and left supramarginal gyrus where also shown to have increasing areas. Conclusion Indeed,there are different effects of taking aripiprazole and risperidone on spontaneous brain activity in schizophrenics,which is consistent with the pharmacological mechanism of two drugs.

关 键 词：阿立哌唑 利培酮 低频振幅 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]