VEGF与EMT相关蛋白E-cadherin在NSCLC中的表达及意义  

Expression and Clinical Significance of VEGF and EMT Associated Protein E-cadherin in NSCLC

作　　者：牛艳清[1] 肖鹏[1] 王云峰[1] 

机构地区：[1]长治医学院病理学教研室,山西长治046000

出　　处：《医学与哲学（B）》2015年第11期64-66,共3页Medicine & Philosophy(B)

摘　　要：研究非小细胞肺癌(NSCLC)组织中血管内皮生长因子(VEGF)和E-钙黏附素(E-cad)的表达情况及临床病理意义。应用免疫组织化学法检测VEGF和E-cad在NSCLC中的表达。二者在NSCLC与肺良性病变组织中的差异均有统计学意义(P<0.05);NSCLC中,VEGF表达与淋巴结转移有关,E-cad表达与肿瘤的分化程度、淋巴结转移以及TNM分期有关(P<0.05);VEGF与E-cad之间呈负相关。二者与NSCLC的发生、发展、侵袭转移有关,可作为判断NSCLC预后的指标。To study the expression and pathological significance of the vascular endothelial growth factor （VEGF） and E-cadherin （E-cad） in NSCLC. Immunohistochemistry was used to detect the expression of VEGF and E-cad in NSCLC. The expressions of VEGF and E-cad in NSCLC and lung benign diseases of comparative differences are statistically significant （P〈0.05） ; In NSCLC , the expression of VEGF is associated with lymph node metastasis, the expression of E cad is correlated with the tumor differentiation, lymph node metastasis and TNM stage （P〈0.05）; between VEGF and E-cad were negatively correlated. Both of them are involved in the occurrence, progress, invasion and matastasis of NSCLC, which can be used as valuable prognostic judgment marker.

关 键 词：非小细胞肺癌 血管内皮生长因子 上皮间质转化 E-钙黏附素 

分 类 号：R734.2[医药卫生—肿瘤]