阿尔茨海默病患者盐酸美金刚治疗前后认知功能变化与事件相关电位P300关系分析  

Correlation between the cognitive function and event related potential P300 in Alzheimer's disease patients before and after the treatment of menantine hydrochloride

作　　者：段敬利[1] 穆俊林[1] 潘伟盟[2] 

机构地区：[1]新乡医学院第二附属医院神经电生理室,河南新乡453002 [2]新乡医学院第二附属医院精神科,河南新乡453002

出　　处：《新乡医学院学报》2015年第12期1122-1124,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨中、重度阿尔茨海默病(AD)患者盐酸美金刚治疗前后认知功能变化与事件相关电位(ERP)P300各项指标的关系。方法对30例AD患者(AD组)于盐酸美金刚治疗前和治疗后16周分别进行简易智能状态检查量表(MMSE)和ERP-P300测试,并与32例健康者(对照组)进行比较。结果 AD组患者治疗前MMSE得分为13.52±2.13,治疗后为18.35±4.32,对照组为26.37±1.63;AD组患者治疗后较治疗前MMSE得分升高,但仍低于对照组,两两比较差异均有统计学意义(P<0.05)。AD组患者治疗前后N1潜伏期及波幅与对照组比较差异均无统计学意义(P>0.05),P2、N2、P3潜伏期均较对照组延长,波幅均较对照组降低(P<0.05);AD组患者治疗后N1、P2、N2潜伏期及N1、P2、N2、P3波幅与治疗前比较差异均无统计学意义(P>0.05),P3潜伏期较治疗前明显缩短(P<0.05),且P3潜伏期和MMSE得分呈负相关(r=-0.678,P<0.05)。结论盐酸美金刚对中重度AD患者认知功能起到一定的改善作用,P3潜伏期可作为AD患者认知功能判定的一项比较客观的指标。Objective To explore the relationship between the cognitive function and indicators of event related potential（ ERP） P300 in moderate to severe Alzheimer＇s disease（ AD） patients before and after the treatment of menantine hydrochloride. Methods ERP-P300 and mini-mental sate examination（ MMSE） tests were done in thirty patients with moderate to severe AD before and after sixteen weeks treatment of menantine hydrochloride; and they were compared with thirty-two health check-ups cases（ control group）. Results The MMSE score of patients in AD group before and after the treatment was13. 52 ± 2. 13 and 18. 35 ± 4. 32 respectively; the MMSE score of cases in control group was 26. 37 ± 1. 63. There was statistic differences of the MMSE score of patients in AD group before and after treatment（ P〈0. 05）; the MMSE score in AD group before and after treatment was significantly lower than that in the control group（ P〈0. 05）. There was no statistic difference of the latency and ampitude of N1 before and after the treatment in the AD group compared with control group（ P〉0. 05）; but the latencies of P2,N2,P3 were longer than those of control group and the ampitudes of P2,N2,P3 were lower than those of control group（ P〈0. 05）. There was no statistic difference of the latency of N1,P2,N2 and the ampitudes of N1,P2,N2,P3 between before and after the treatment（ P〉0. 05）; the latency of P3 after the treatment was shorter than that of before treatment（ P〈0. 05）; and the latency of P3 was negatively correlated with the MMSE score（ r =- 0. 678,P〈0. 05）. Conclusion Memantine hydrochloride can improve the cognitive function of the moderate to severe Alzheimer＇s patients,and the latency of P3 can be used as a relatively objective indicator for assessment the cognitive function.

关 键 词：阿尔茨海默病 盐酸美金刚 事件相关电位P300 认知功能 

分 类 号：R749[医药卫生—神经病学与精神病学]