牛磺酸消炎抗氧化机理及其在幼龄动物中的应用  

Anti-Inflammatory and Antioxidant Mechanism of Taurine and Its Application in Young Animals

作　　者：徐玲[1] 王庆争 杜孝贵 曹伟平 唐志如[1] 张小龙[1] 

机构地区：[1]西南大学动物科技学院,生物饲料与分子营养实验室,重庆400715 [2]湖南省永兴县樟树中学,郴州423311

出　　处：《动物营养学报》2015年第12期3683-3688,共6页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：雅琪创新基金项目(YQ 201401);国家973重点基础研究发展计划项目(2013CB127303);农业部948项目(2015Z74);中央高校基本业务费专项资金(XDJK2014B028,XDJK2015D005)

摘　　要：牛磺酸广泛存在于动物组织细胞内,具有消炎抗氧化生物学功能。目前研究发现牛磺酸消炎抗氧化机理包括:通过雷帕霉素靶蛋白(m TOR)信号通路促进肠黏膜修复,通过抑制Toll样受体4(TLR4)信号通路缓解肠黏膜炎症反应,通过瞬时受体电位通道M2(TRPM2)离子通道改善细胞线粒体生理功能。本文就牛磺酸消炎抗氧化机理以及在幼龄动物中的应用进行综述,以期为牛磺酸在消炎抗氧化方面研究提供参考意义。Taurine is widely found in the cells of animal tissues and has anti-inflammatory and antioxidant biological function. Recent studies have found that anti-inflammatory and anti-oxidative mechanism of taurine is as follows： taurine promotes the repair of intestinal mucosa through mammalian target of rapamyein（ mTOR） signaling pathway; taurine alleviates the inflammatory reaction of intestinal mucosa by inhibiting Toll-like-receptors（ TLR4） signaling pathway; taurine improves mitochondrial function in cell physiology through the transient receptor potential melastatin type 2（ TRPM2） ion channels. In order to provide reference significance for taurine in anti-inflammatory and anti-oxidative research,the anti-inflammatory and anti-oxidative mechanism of taurine and the application of taurine in the young animals were reviewed in this paper.

关 键 词：牛磺酸 消炎 抗氧化 幼龄动物 

分 类 号：S811.2[农业科学—畜牧学]