肠道菌群及防御素在结直肠癌发病中的作用  

Role of intestinal flora and defensins in colorectal carcinogenesis

作　　者：马丹[1] 杨帆[1] 方军[1] 王树玲[1] 李兆申[1] 柏愚[1] 

机构地区：[1]上海第二军医大学长海医院消化内科,上海市200433

出　　处：《世界华人消化杂志》2015年第33期5275-5281,共7页World Chinese Journal of Digestology

基　　金：第二军医大学优秀青年学者基金资助项目;2014年上海市青年科技启明星计划(A类)基金资助项目;No.14QA1404800~~

摘　　要：结直肠癌是消化系常见的恶性肿瘤之一.近年来,我国结直肠癌的发病率和死亡率呈持续上升趋势,造成沉重的医疗负担,但其确切病因仍然未知.因此,推进结直肠癌病因和发病机制的相关研究,进而开展早期预防,有效筛查和靶向治疗是一项迫切的医学任务.目前,肠道菌群与结直肠癌的相关性研究不断深入,而防御素(defensin)作为肠道菌群与肠道黏膜相互作用的介质之一,其在结直肠癌发生发展中的潜在地位也逐渐引起关注.本文对人体肠道菌群及防御素进行了简要介绍,并对二者在结直肠癌发病中的作用及其可能机制相关研究进展进行了回顾,另外还初步探索了二者之间的相互影响作用.Colorectal cancer is a common malignant tumor of the digestive system.In recent years,the morbidity and mortality of colorectal cancer in China have been rising continuously,causing heavy medical burden;however,the exact etiology is still unknown.Therefore,there is an urgent need to elucidate the etiology and pathogenesis of colorectal cancer to promote early prevention,effective screening and targeted therapy.At present,the research on the correlation between intestinal flora and colorectal cancer is being deepened constantly.Defensins,mediating interaction between intestinal flora and the intestinal mucosa,have attracted more and more attention because of their potential role in the development of colorectal cancer.Here we briefly introduce human intestinal flora and defensins,review new advances in our understanding of their role in colorectal carcinogenesis and the possible mechanism,and preliminarily explore their mutual interaction.

关 键 词：结直肠癌 肿瘤发生 肠道菌群 防御素 

分 类 号：R735.34[医药卫生—肿瘤]