金龙胶囊联合放化疗治疗非小细胞肺癌的Meta分析  

Jinlong capsule combined with chemoradiotherapy for NSCLC: a Meta-analysis

作　　者：鲁强[1] 罗景斌 冯毅凡[1] 佘琴[1] 石忠峰[1] 

机构地区：[1]广东药学院中心实验室,广东广州510006

出　　处：《中国中药杂志》2015年第22期4491-4496,共6页China Journal of Chinese Materia Medica

摘　　要：运用Meta分析评价口服金龙胶囊联合放化疗治疗非小细胞肺癌的疗效和安全性。对PubMed,Embase,CNKI和万方数据库进行科学检索,没有语言限制,检索时间从1990年1月至2015年7月,纳入符合该研究要求的文献,对纳入的文献进行数据提取和质量评价。使用RevMan 5.3软件进行数据统计分析。最终纳入10个研究,736名患者,其中口服金龙胶囊联合放化疗组370名,单纯放化疗组366名。Meta分析结果显示,与单纯放化疗相比,口服金龙胶囊联合放化疗治疗非小细胞肺癌能够显著提高临床治疗有效率（OR=1.77,95%CI：1.29~2.43,P〈0.05）、临床受益率（OR=1.89,95%CI：1.22~2.91,P〈0.05）和生活质量改善率（OR=2.56,95%CI：1.61~4.05,P〈0.05）,减少白细胞下降发生率（OR=0.35,95%CI：0.22~0.56,P〈0.05）和胃肠道反应发生率（OR=0.67,95%CI：0.40~1.11,P〈0.05）。合并的结果表明,口服金龙胶囊联合放化疗治疗非小细胞肺癌可以提高患者的临床疗效,改善生活质量和降低不良反应。The purpose of this study was to evaluate the effect and safety of Jinlong capsule combined with chemotherapy or radiotherapy for non-small cell lung cancer（ NSCLS） using Meta-analysis. Pub Med,Embase,CNKI and Wanfang databases were all searched without language restriction,and searching time was from January 1990 to July 2015. All eligible published studies were included in this study for quality assessment and data extraction. All the data were analyzed using Revman 5. 3. A total of ten studies including 736 subjects（ 370 in Jinlong capsule plus chemoradiotherapy and 366 in chemoradiotherapy only） were finally included in this Meta-analysis. The result of Meta analysis showed that compared with pure chemoradiotherapy group,Jinlong capsule combined with chemoradiotherapy for NSCLC could improve the patients＇ curative effect（ OR = 1. 77,95% CI： 1. 29-2. 43,P 0. 05）,clinical benefit rate（ OR = 1. 89,95% CI： 1. 22-2. 91,P 0. 05）,life quality improvement rate（ OR = 2. 56,95% CI： 1. 61-4. 05,P 0. 05）,and decrease leucopenia incidence rate（ OR = 0. 35,95% CI： 0. 22-0. 56,P 0. 05） and gastrointestinal reaction rate（ OR = 0. 67,95% CI： 0. 40-1. 11,P 0. 05）. The pooled results showed that Jinlong capsule combined with chemoradiotherapy for NSCLC could improve the curative effect and life quality,and decrease the adverse reaction of patients.

关 键 词：金龙胶囊 非小细胞肺癌 META分析 

分 类 号：R734.2[医药卫生—肿瘤]