杨桃根总提物对高血脂症大鼠的影响  

Effect of total extracts of Averrhoa carambola L.(Oxalidaceae)roots in experimental hyperlipidemia rats

作　　者：唐静芝[1] 黄婉苏 李菊满[1] 农志欢[1] 黄仁彬[1] 

机构地区：[1]广西医科大学药理学教研室,南宁530021

出　　处：《中国临床药理学杂志》2015年第24期2444-2447,共4页The Chinese Journal of Clinical Pharmacology

基　　金：广西科学研究与科技开发攻关基金资助项目(桂科攻10124008-6;桂科攻0992003A-2);广西科技基础条件平台建设基金资助项目(12-97-20;10-108-19);广西地方性高发疾病防治研究重点实验室基金资助项目(KFJJ2010-22)

摘　　要：目的研究杨桃根总提物(TEACLR)对高血脂大鼠降血脂和保肝的作用。方法选取60只健康SD大鼠建立高脂血症模型后将60只高脂血症大鼠按血清TC水平随机分成6组(每组10只雌雄各半):空白组、模型组、阳性对照组(2.5 mg·kg^(-1)·d^(-1))、3个剂量TEACLR组(1200,600,300 mg·kg^(-1)·d^(-1)),每天灌胃一次,空白组和模型组灌服蒸馏水,连续给药5周。末次给药后,称重,取血,取肝,自动生化仪检测血脂相关指标,用试剂盒检测肝组织相关指标。结果与模型组比较TEACLR能降低总胆固醇、三酰甘油、低密度脂蛋白胆固醇、碱性磷酸酶及丙二醛的水平[分别为(2.48±0.43),(0.86±0.44),(0.86±0.43)mmol·L^(-1)和(165.55±71.71)U·L^(-1),(1.38±0.42)nmol·prot^(-1)],升高高密度脂蛋白胆固醇、谷胱甘肽的活性[1.67±0.32)mmol·L^(-1),(3.43±0.78)nmol·prot^(-1)],明显降低肝系数(2.92±0.03),600 mg·kg^(-1)·d^(-1)TEACLR组能降低血清谷丙转氨酶(ALT)与谷草转氨酶(AST)水平[38.91±10.47),(99.91±30.74)U·L^(-1)],高剂量TEACLR组能明显升高超氧化物歧化酶活性(24.44±3.13)nmol·prot^(-1)(P<0.01或P<0.05);与空白组、阳性对照组组比较,600mg·kg^(-1)·d^(-1)TEACLR组的各项实验结果差异均无统计学意义(P>0.05)。结论 TEACLR具有显著降低血脂、减轻脂肪肝作用。Objective To study the effects of total extracts of Averrhoa carambola L.（Oxalidaceae） roots（TEACLR） in hyperlipidemia rats.Methods Sixty SD rats（male and female in half） were subjected to induction of hyperlipidemia by high- fat diet for established hyperlipidemia rat model and were divided into the following groups：blank group,model group,positive control group（simvastatin 2.5 mg · kg^-1 · d ^-1orally）,TEACLR high,middle and low doses groups.Hyperlipidemia rats were treated with TEACLR,at doses of 1200,600 and 300mg·kg^-1 · d^-1 for 5 weeks by gavages,respectively.After 5- week of treatment with drugs,blood sample and liver were collected for determination.Results In contrast to the model group,TEACLR could reduce the contents of cholesterol,triglyceride,low- density lipoprotein,alkaline phosphatase in rat serum and liver malondialdehyde reduced obviously[（2.48 ± 0.43）,（0.86 ± 0.44）,（0.86 ± 0.43） mmol·L^-1 and（165.55±71.71） U·L^-1,（1.38±0.42） nmol · prot^-1,respectively].The level of high- density lipoprotein and glutathione elevated evidently[（1.67 ± 0.32） mmol · L^-1,（3.43 ± 0.78） nmol · prot^-1].Liver coefficient was significantly lowered（2.92±0.03）.TEACLR middle dose group could reduce the contents of alanine aminotransferase（ALT） and aspartate aminotransferase（AST） obviously[（38.91±10.47）,（99.91±30.74）U · L^-1].TEACLR high dose group could increase the contents of superoxide dismutase evidently（24.44±3.13） nmo· prot^-1.Comparison with blank group and positive control group,there was no significant difference in TEACLR middle dose group.Conclusion TEACLR is proven to be able to decrease the level of hyperlipidemia markedly,which might be used as an effective therapeutic agent for hyperlipidemia and fatty liver.

关 键 词：高血脂 杨桃根总提物 降血脂 保护肝 

分 类 号：R972.6[医药卫生—药品] R285.5[医药卫生—药学]